Can Selen help with longevity?

Selenium is an essential trace mineral that functions as a component of selenoproteins (e.g., glutathione peroxidases) with antioxidant and anti-inflammatory roles. Some observational studies suggest an association between optimal selenium status and reduced all-cause mortality, particularly in older adults. However, evidence for a direct longevity benefit in humans is weak to moderate. Randomized controlled trials have not demonstrated clear anti-aging effects from selenium supplementation in well-nourished individuals. Excess selenium can be toxic (selenosis) and may increase the risk of type 2 diabetes. Genetic variants in selenoprotein genes (e.g., GPX1, SEPP1) can influence individual requirements, but consumer DNA tests rarely provide clinically actionable insights. Marketing claims that selenium promotes longevity are often exaggerated, relying on animal studies or weak associations. A balanced diet (e.g., Brazil nuts, fish, eggs) typically meets needs. Supplementation is only recommended for diagnosed deficiency. In summary, selenium is necessary for health but not a proven longevity enhancer. The evidence does not support its use as an anti-aging supplement in healthy individuals.