TSH (thyroid-stimulating hormone) is a well-established screening marker for thyroid dysfunction, which can cause fatigue. Hypothyroidism (elevated TSH) or hyperthyroidism (low TSH) often present with exhaustion. However, fatigue is non-specific – many other factors like sleep deprivation, stress, iron deficiency, or depression play a role. An isolated TSH value alone is insufficient to explain fatigue; it should be interpreted alongside fT3, fT4, antibodies, and clinical symptoms. Consumer lab tests that measure TSH can provide a first hint but cannot diagnose. If values are abnormal, medical follow-up is necessary. Evidence is human-strong for the role of thyroid in fatigue, but test accuracy and interpretation depend on the method. Caution: a normal TSH does not completely rule out thyroid issues (e.g., subclinical cases).
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