Can tTG IgA help with Darmgesundheit?

tTG IgA (tissue transglutaminase IgA) is a well-established biomarker for celiac disease, an autoimmune gut disorder triggered by gluten. When celiac disease is suspected (e.g., chronic diarrhea, bloating, fatigue), the test has high sensitivity and specificity and is clinically indicated. For general gut health without specific celiac suspicion, tTG IgA is not useful – a positive result may indicate celiac disease, but a negative result does not rule out other gut issues like IBS or IBD. Additionally, IgA deficiency can cause false negatives. The test should only be used when symptoms or risk factors (e.g., family history) are present. Ordering it without medical context is not recommended. Evidence: strong clinical validation for celiac disease, but not for general gut health assessment.