Myths vs facts: VKORC1 and Fruchtbarkeit

Claims linking VKORC1 to fertility are not supported by scientific evidence. VKORC1 encodes an enzyme central to vitamin K metabolism and blood coagulation; its primary clinical relevance is in pharmacogenetics, where variants predict warfarin dose requirements. No well-designed studies have demonstrated a direct association between VKORC1 polymorphisms and fertility outcomes such as ovulation, sperm quality, or implantation. Hypotheses about vitamin K-dependent proteins in reproductive tissues remain speculative. The evidence level is best described as 'unclear' or 'marketing', as direct-to-consumer genetic tests often overstate implications. For fertility concerns, clinically validated factors – age, hormonal balance, lifestyle, and organic pathology – are far more relevant. A VKORC1 test does not provide actionable fertility insights and may mislead consumers.