Evidence check: Selen in the context of Wechseljahre

Selenium is an essential trace element important for thyroid function and antioxidant defense. During menopause, oxidative stress increases, and some observational studies suggest selenium may support cognition or bone health. However, evidence for routine selenium supplementation in menopause is limited and mostly mechanistic. Before supplementing, a blood test (serum selenium) is recommended to avoid toxicity (>300 µg/day can cause selenosis). The recommended dietary allowance for women is 55 µg/day (US) or 60 µg/day (Germany). Genetic variants (e.g., in SELENOP or GPX1) may influence selenium metabolism but do not justify supplementation without lab confirmation. Overall, selenium is relevant but not a standalone solution for menopausal symptoms. Evidence: human-moderate/mechanistic.