Is HLA-DQ2 useful for Sport?

HLA-DQ2 is a genetic marker strongly associated with celiac disease. For sport, this test is only useful if an athlete experiences symptoms like chronic fatigue, bloating, or unexplained performance decline that could indicate gluten intolerance. A negative HLA-DQ2 effectively rules out celiac disease, but a positive result alone does not confirm the disease – serology and duodenal biopsy are required. Evidence comes from clinical practice, not sports-specific studies. Many athletes adopt gluten-free diets without medical need; HLA-DQ2 testing in this context is often unnecessary and may lead to misinterpretation. For genuine digestive or performance issues, medical workup is more appropriate than genetic testing. Its utility for sport is therefore limited.