HsCRP (high-sensitivity C-reactive protein) is a biomarker of systemic inflammation. Elevated hsCRP levels are associated with poor sleep quality, shorter sleep duration, and insomnia in observational studies. The mechanism likely involves inflammation disrupting sleep-regulating pathways. However, hsCRP is not a diagnostic tool for sleep disorders; it reflects inflammation, which can be influenced by many factors (e.g., diet, stress, obesity, infection). Evidence is human-observational (moderate), not from interventional trials. A normal hsCRP does not rule out sleep issues, and an elevated level does not confirm a sleep problem. Consumer tests like MyBody-X may include hsCRP in health panels, but it should not be used alone to assess or treat sleep. For sleep concerns, focus on sleep hygiene, cognitive behavioral therapy, and medical evaluation. Caveat: No clinical guidelines support hsCRP for sleep assessment.
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