Can CYP1A2 help with skin aging?

CYP1A2 is primarily known for metabolizing caffeine and certain drugs. A direct, clinically relevant link to skin aging is not established. There are mechanistic suggestions that CYP1A2 could influence the metabolism of endogenous compounds like melatonin or estrogens, which might theoretically affect skin aging via antioxidant or hormonal pathways. However, robust human studies demonstrating a causal role of CYP1A2 variants in skin aging or wrinkle formation are lacking. Effect sizes of known SNPs are very small, and the evidence is largely speculative. For improving skin health, one should focus on proven factors such as sun protection, diet, sleep, and avoiding smoking. A genetic test for CYP1A2 currently provides no clinically actionable information regarding skin aging.