What can the Cardio Risk Check | Herz-Kreislauf Risiko-Test tell you — and what not?

The Cardio Risk Check (Herz-Kreislauf Risiko-Test) from MyBody-X analyzes selected genetic markers linked to lipid metabolism, blood pressure regulation, and inflammatory processes. It can indicate a genetic predisposition for elevated cholesterol (e.g., via APOE, LDLR) or blood pressure sensitivity (e.g., via AGT). Lifestyle factors like diet and exercise are often integrated to create a personalized risk profile. **What it cannot do:** It does not replace a clinical diagnosis. Many tested variants have small effect sizes (OR < 1.5) and are population-dependent. The test does not capture classic risk factors like smoking, diabetes, or hypertension unless separately entered. Rare but clinically relevant mutations (e.g., familial hypercholesterolemia) are not always covered. Results are probabilities, not definitive predictions. **Evidence base:** Most associations come from GWAS with moderate effect sizes. Some markers (e.g., rs1801282 in PPARG) have mechanistic evidence, but clinical relevance is often unclear. The test is intended as a complementary tool, not a standalone basis for medical decisions. **Safety note:** Individuals with existing cardiovascular disease or medication should discuss results with a physician. The test cannot detect acute risks.