Myths vs facts: Testosteron and Langlebigkeit

Myths vs. Facts: Testosterone and Longevity Myth: "Higher testosterone extends lifespan." Fact: The TRAVERSE RCT confirmed cardiovascular safety of TRT in hypogonadal men but found no significant longevity benefit. A direct causal link between testosterone levels and lifespan is not established. Myth: "Genetic tests can tell me my optimal testosterone." Fact: GWAS show many small-effect variants (e.g., SHBG, AR CAG) influence testosterone, but consumer DNA tests lack predictive power for hormone levels. The VDR genotype, per context, has no direct effect on sex hormones. Blood tests remain more reliable. Myth: "Low testosterone always means premature aging." Fact: A single low morning cortisol or testosterone value is not diagnostic. Hormones fluctuate; confirmatory testing by an endocrinologist is required. Self-medication with steroids is dangerous. Conclusion: Testosterone is one piece of the longevity puzzle, not a silver bullet. Lifestyle factors (diet, exercise, sleep) and other biomarkers (e.g., vitamin B12, microbiome) are equally important. Evidence: human-moderate.