What role does Folsäure play in fertility?

Folic acid (vitamin B9) is essential for DNA synthesis and cell division – processes critical for fertility and early embryonic development. Deficiency increases the risk of neural tube defects, so supplementation before and during early pregnancy is standard. For those trying to conceive, 400–800 µg daily is commonly advised. Genetic variants in the MTHFR gene can modestly affect folate metabolism, but clinical impact is usually small. Blood tests for folate, B12, and homocysteine are more actionable than DNA results alone. Evidence for a direct fertility benefit (e.g., ovulation, sperm quality) is moderate and mostly from observational studies. High doses without medical supervision are not recommended, as they can mask B12 deficiency. In summary: folic acid is an important component but not a standalone solution for fertility issues.