A genetic test for celiac disease (e.g., HLA-DQA1, rs2071559) indicates only genetic risk, not the disease itself. Many carriers never develop celiac. Fatigue can be a symptom of celiac (due to malabsorption, iron deficiency, or chronic inflammation), but also has many other causes (thyroid issues, sleep deprivation, stress, other nutrient deficiencies). The test alone is insufficient for diagnosis. If celiac is suspected, serological tests (tTG-IgA) and duodenal biopsy are the gold standard. A positive genetic test without symptoms or antibodies does not justify a gluten-free diet. Additionally, fatigue and celiac may be linked to gut microbiome disturbances – the article on rebuilding gut flora after diarrhea highlights the importance of gut health. Seek medical advice before changing your diet.
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