CRP (C-reactive protein) is an inflammation marker, not a direct blood-sugar-lowering agent. Chronically elevated CRP indicates systemic inflammation, which is strongly linked to insulin resistance and impaired glucose metabolism. Reducing inflammation through diet, exercise, or weight loss can improve insulin sensitivity and help regulate blood sugar. However, CRP itself is not a therapeutic target; it is a risk marker. Trials targeting CRP reduction (e.g., with statins) show modest effects on glycemia. The evidence for a causal role of CRP in blood sugar control is moderate (human-moderate). Caveat: single CRP measurements are non-specific; lifestyle interventions should address overall metabolic health rather than just one biomarker.
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