Myths vs facts: Leaky Gut Test and fertility

Finding rs1801133 (MTHFR C677T) in a DNA test does not directly indicate fertility problems. This variant affects folate metabolism and is very common (carrier frequency ~36% in Europeans). Some studies suggest a possible link between MTHFR variants, elevated homocysteine, and fertility issues, but the evidence is weak and inconsistent. Most people with this variant have no fertility problems. Consumer genetic tests often overstate the clinical relevance of single SNPs. Fertility is multifactorial – age, hormones, lifestyle, environment, and many genetic factors play a role. A single SNP cannot predict fertility. If you have specific fertility concerns, consult a reproductive specialist for comprehensive testing, not just a DNA chip.