How are Selen and menopause related?

The relationship between selenium and menopause is not clearly established in the scientific literature. Selenium is an essential trace element that, as part of selenoproteins, has antioxidant and thyroid-regulating functions. During menopause, estrogen levels decline, which can promote oxidative stress and inflammatory processes. Some observational studies suggest that adequate selenium status may be associated with milder menopausal symptoms (e.g., fewer hot flashes) and a more favorable lipid profile. However, randomized controlled trials proving a causal benefit of selenium supplementation during menopause are lacking. The evidence is therefore considered moderate. Moreover, selenium overdose is toxic (selenosis). Without prior laboratory testing, high-dose selenium should not be taken. Individual genetic predisposition (e.g., variants in selenoprotein genes) could influence selenium utilization, but sufficient data for menopause are not available. In summary: selenium is relevant, but supplementation is only advisable if deficiency is confirmed and under medical supervision.