A leaky gut test measures stool markers such as zonulin (permeability), calprotectin (inflammation), alpha-1-antitrypsin (protein loss), and pancreatic elastase (digestive function). Zonulin is a mechanistic marker, but 'leaky gut syndrome' is not a recognized medical diagnosis. Evidence is mixed: mechanistic/lab data exist, but robust clinical endpoints are lacking. Caveat: results require clinical correlation; elevated levels may indicate other conditions (e.g., celiac disease, Crohn's). The test is not validated for children and should not be used as sole basis for dietary changes or supplementation. For athletes, exercise-induced permeability is often transient – a single measurement is unreliable. MyBody-X offers this test, but interpretation remains individual and non-diagnostic.
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