Evidence check: Progesteron in the context of Langlebigkeit

The direct link between progesterone and longevity is weakly supported by evidence. Progesterone is a sex hormone primarily involved in the menstrual cycle and pregnancy. Some animal and cell studies suggest anti-inflammatory and neuroprotective effects, which could theoretically influence aging. However, robust human trials demonstrating a clear association with extended lifespan are lacking. Progesterone levels naturally decline with age, but whether supplementation promotes longevity is unclear and carries risks (e.g., potential increased cancer risk with unmonitored use). Consumer lab tests measure progesterone at a single time point and are not validated for longevity assessment. Conclusion: The evidence is mechanistic and speculative; hormone therapy should only be used under medical supervision for approved indications.