Can COMT help with menopause?

The COMT gene variant (rs4680, Val158Met) influences the breakdown of catecholamines and estrogens. In menopause, slower COMT activity (Met allele) may lead to higher estrogen levels, potentially easing hot flashes but possibly increasing breast cancer risk. However, evidence is mostly mechanistic and from observational studies; robust clinical trials are lacking. A single genetic test cannot reliably predict or guide menopause management. Hormonal changes are multifactorial, and lifestyle, diet, and medical supervision remain key. Caveat: Do not base hormone therapy or supplement decisions solely on a COMT result. Consult a healthcare provider for personalized advice.