What role does Progesteron play in skin aging?

Progesterone plays a role in skin aging, but the evidence is less robust than for estrogen. Progesterone receptors are present in skin cells (fibroblasts, keratinocytes). Studies suggest that progesterone can stimulate collagen synthesis, improve skin density, and regulate sebum production. During menopause, declining progesterone levels may contribute to skin dryness, loss of elasticity, and wrinkle formation. However, effects are dose-dependent and not uniform: some studies show positive effects on skin hydration and thickness, while others find no significant changes. The clinical use of topical progesterone for skin rejuvenation is controversial and not well-supported by large, randomized trials. Additionally, systemic hormone therapy carries risks. Overall, progesterone's role in skin aging is considered moderate and context-dependent, with stronger evidence when combined with estrogen in hormone replacement therapy.