CRP (C-reactive protein) is a non-specific marker of inflammation measured in blood. Elevated CRP can indicate systemic inflammation that may involve the gut – for example in inflammatory bowel diseases (IBD) like Crohn's disease or ulcerative colitis. However, CRP is not a specific marker for gut health: it rises in many infections, tissue damage, or autoimmune conditions without pinpointing the cause. For assessing the gut microbiome or functional disorders (e.g., irritable bowel syndrome), CRP is of limited value. Stool-based tests like calprotectin or microbiome analysis are more targeted. The evidence for CRP as a 'gut health marker' is weak – it is a mechanistic but not diagnostic parameter. A normal CRP does not rule out gut issues, and an elevated level requires medical follow-up. To truly understand gut health, more specific methods are recommended.
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