Myths vs facts: CYP1A2 and skin aging

The claim that CYP1A2 genotype directly influences skin aging is largely a myth, often promoted by direct-to-consumer DNA tests. CYP1A2 is primarily involved in caffeine and drug metabolism, not in skin structure. While some research suggests a possible link via oxidative stress, the evidence is weak and inconsistent. Skin aging is predominantly driven by UV exposure, lifestyle factors (smoking, diet), and collagen metabolism. Consumer genetics tests that claim to predict skin aging based on CYP1A2 variants are not supported by robust clinical data. For evidence-based anti-aging strategies, focus on sun protection, antioxidants, and a healthy lifestyle rather than single-gene interpretations.