How are Testosteron and skin aging related?

Testosterone influences skin aging through multiple pathways: androgen receptors in fibroblasts and sebaceous glands regulate collagen synthesis, sebum production, and skin thickness. Declining testosterone with age (andropause) is associated with reduced dermal density, increased wrinkling, and loss of elasticity. Conversely, excess testosterone (e.g., in PCOS) can promote acne and seborrhea. Evidence is largely observational and mechanistic; randomized controlled trials on testosterone therapy for skin aging are scarce and show mixed results. Hormone therapy is not approved for skin rejuvenation and carries risks (cardiovascular, prostate). Genetic factors like androgen receptor CAG repeats modulate sensitivity, but direct-to-consumer tests lack clinical validation. Conclusion: a link exists, but clinical application is limited and requires medical supervision.