Myths vs facts: Magnesium and allergy

Magnesium is frequently marketed as a remedy for allergies, but the scientific evidence is weak. Mechanistic studies suggest magnesium can inhibit histamine release from mast cells and exert anti-inflammatory effects, primarily in vitro and in animal models. A few small human trials hint at modest benefits for allergic rhinitis or asthma, but results are inconsistent and study quality is generally low. Frank magnesium deficiency is uncommon, and even when present, it is unclear whether supplementation improves allergy symptoms. Importantly, high-dose magnesium supplements (>350 mg elemental magnesium per day) can cause diarrhea, nausea, and in renal impairment, dangerous hypermagnesemia. The evidence does not support routine use for allergy treatment. If supplementation is considered, it should be discussed with a physician, and well-absorbed forms like magnesium citrate or glycinate are preferable. Overall: Mechanistically plausible but clinically unproven – more myth than fact.