Glucose and skin are linked through glycation: excess blood glucose binds to collagen and elastin fibers, forming Advanced Glycation Endproducts (AGEs). These AGEs stiffen the fibers, reduce skin elasticity, and promote wrinkling and yellowing. The process is accelerated by high blood sugar, e.g., in diabetes or high-sugar diets. Antioxidants like vitamin C and E may partially reduce AGE formation, but evidence for clinically meaningful effects is moderate. MyBody-X DNA tests claiming to predict genetic susceptibility to skin glycation lack solid validation – skin aging is predominantly environmental (diet, UV exposure). A blood test for HbA1c or fasting glucose provides more direct risk assessment. Caveat: high-dose antioxidant supplements can be harmful. Evidence: mechanistic/human-moderate.
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