Is Triglyceride senken useful for Langlebigkeit?

Whether lowering triglycerides directly promotes longevity is not clearly established by evidence. Elevated triglycerides are a risk factor for cardiovascular disease, which can reduce life expectancy. However, randomized controlled trials specifically targeting triglyceride reduction (e.g., with fibrates) have not consistently shown a reduction in all-cause mortality. Most evidence comes from observational studies and subgroup analyses of statin trials. Lifestyle interventions—weight loss, Mediterranean diet, exercise—lower triglycerides and improve overall cardiometabolic health, making a longevity benefit plausible but not attributable to triglycerides alone. Genetic variants associated with triglyceride levels (e.g., in LPL) have small effect sizes and no established clinical utility for the general population. Direct-to-consumer DNA tests claiming to guide triglyceride management lack robust validation. Without medical supervision, self-supplementation or medication is not advised. Overall, the evidence is mixed: mechanistic and observational support exists, but strong interventional proof for a causal effect on longevity is absent.