warum nehme ich immer mehr zu — which blood markers matter?

Weight gain is multifactorial, and no single blood marker tells the whole story. However, certain markers can point to underlying issues. Key ones include: fasting glucose and HbA1c (insulin resistance or prediabetes), TSH (hypothyroidism), CRP (inflammation often linked to obesity), and cortisol (elevated in chronic stress, promoting abdominal fat). Homocysteine and MMA are useful for B12/folate status but not directly tied to weight gain. DNA variants like APOA2 CC show modest, ancestry-specific effects and are not clinically actionable for weight management. Evidence quality is mixed: strong clinical guidelines support TSH and glucose testing; moderate observational data support CRP and cortisol; DNA associations are based on GWAS with small effect sizes. Caveats: acute infections can raise CRP; cortisol fluctuates daily. Always consult a physician for interpretation. Sustainable weight control typically requires diet, exercise, stress reduction, and sleep—no single lab value explains the full picture.