{"count":2,"index":{"built_at":"2026-07-27T19:13:49.384467+00:00","public_records":55311,"revision":"be6678e3ec0b72a5beac5f35"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: tTG IgA in the context of Haut"},"results":[{"answer":"tTG IgA (tissue transglutaminase IgA) is a well-established serological marker for celiac disease. In the context of skin, the strongest link is with dermatitis herpetiformis (Duhring's disease), a gluten-sensitive skin condition where tTG IgA is often elevated. Evidence for this association is human-strong (multiple studies, guidelines). However, tTG IgA is not a direct skin test; it is measured in blood. For non-specific skin issues (e.g., eczema, acne) without celiac suspicion, its utility is unclear – many direct-to-consumer tests market tTG IgA as a 'gluten sensitivity marker', but evidence for non-celiac gluten sensitivity is weak. Caveat: A positive tTG IgA result always requires gastroenterological follow-up (duodenal biopsy). For skin symptoms, additional skin biopsy for IgA deposits is recommended. Testing without clinical indication may lead to misinterpretation.","area":"gesundheit","canonical_id":"gesundheit:canonical-4a00ada104c9a268dcf58db7","id":"public-8b016a28c01b939fab12480b","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: tTG IgA in the context of Haut","score":30.22654928,"snippet":"tTG IgA (tissue transglutaminase IgA) is a well-established serological marker for celiac disease. In the context of skin, the strongest link is with dermatitis herpetiformis (Duhring's disease), a gluten-sensitive skin condition where tTG IgA is often elevated. Evidence for this association is human-strong (multiple studies, guidelines). However, tTG IgA is not a direct skin test; it is measured in blood. For non-specific skin issues (e.g., eczema, acne) without celiac suspicion, its utility is unclear – many direct-to-consumer tests market tTG IgA as a 'gluten sensitivity marker', but evidence for non-celiac gluten sensitivity is weak. Caveat: A positive tTG IgA result always requires gast","sources":[],"title":"Evidence check: tTG IgA in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-8b016a28c01b939fab12480b/evidence-check-ttg-iga-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"A celiac test in the context of skin symptoms is medically relevant, especially when dermatitis herpetiformis (DH) is suspected – a classic skin manifestation of celiac disease. Diagnosis relies on serological markers (IgA antibodies against tissue transglutaminase, tTG) and, if needed, duodenal biopsy. The evidence for this link is strong (human-strong): nearly all DH patients have underlying celiac disease, and a gluten-free diet resolves both gut and skin lesions. However, a consumer DNA test for HLA-DQ2/DQ8 can only indicate genetic risk, not active disease. Most people with these genes never develop celiac disease. MyBody-X tests are lifestyle products, not medical devices. For skin symptoms, a physician should order appropriate serology. Evidence for standalone genetic risk tests is weak (gwas/mixed).","area":"gesundheit","canonical_id":"gesundheit:canonical-a4bc67d6f98f6cc1d8b30a50","id":"public-f91326e2c8e42a8549b7b404","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Zöliakie Test in the context of Haut","score":26.62482419,"snippet":"A celiac test in the context of skin symptoms is medically relevant, especially when dermatitis herpetiformis (DH) is suspected – a classic skin manifestation of celiac disease. Diagnosis relies on serological markers (IgA antibodies against tissue transglutaminase, tTG) and, if needed, duodenal biopsy. The evidence for this link is strong (human-strong): nearly all DH patients have underlying celiac disease, and a gluten-free diet resolves both gut and skin lesions. However, a consumer DNA test for HLA-DQ2/DQ8 can only indicate genetic risk, not active disease. Most people with these genes never develop celiac disease. MyBody-X tests are lifestyle products, not medical devices. For skin sym","sources":[],"title":"Evidence check: Zöliakie Test in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-f91326e2c8e42a8549b7b404/evidence-check-zoeliakie-test-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}