{"count":10,"index":{"built_at":"2026-07-27T05:30:59.945704+00:00","public_records":55311,"revision":"4424fa006b170f8be59032fe"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Vitamin D Test in the context of Sport"},"results":[{"answer":"The evidence for routine Vitamin D testing in athletes is mixed. Vitamin D is essential for bone health, immune function, and possibly muscle strength. Deficiency can impair performance and recovery. However, the benefit of testing asymptomatic athletes without risk factors (e.g., limited sun exposure, dark skin) is not clearly established. Most guidelines recommend testing only when deficiency is suspected or in high-risk groups. Reference ranges vary, and the correlation between serum levels and athletic performance is weak. Testing may be useful if it leads to targeted supplementation, but overinterpretation of single values should be avoided. Overall, the evidence combines physiological plausibility with limited clinical proof. Direct-to-consumer tests further lack standardization, reducing reliability.","area":"gesundheit","canonical_id":"gesundheit:canonical-101299ceb9dd9d344104fc0c","id":"public-9e08ce54201505e6b48ef7d6","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D Test in the context of Sport","score":17.49989836,"snippet":"The evidence for routine Vitamin D testing in athletes is mixed. Vitamin D is essential for bone health, immune function, and possibly muscle strength. Deficiency can impair performance and recovery. However, the benefit of testing asymptomatic athletes without risk factors (e.g., limited sun exposure, dark skin) is not clearly established. Most guidelines recommend testing only when deficiency is suspected or in high-risk groups. Reference ranges vary, and the correlation between serum levels and athletic performance is weak. Testing may be useful if it leads to targeted supplementation, but overinterpretation of single values should be avoided. Overall, the evidence combines physiological ","sources":[],"title":"Evidence check: Vitamin D Test in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-9e08ce54201505e6b48ef7d6/evidence-check-vitamin-d-test-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Measuring 25-hydroxyvitamin D (25-OH vitamin D) in the context of sport is relevant because vitamin D is critical for bone health, muscle function, immune defense, and inflammation regulation. Deficiency can impair recovery, increase injury risk, and reduce performance. The evidence is nuanced: observational studies link low vitamin D levels with reduced muscle strength and higher infection rates. Randomized controlled trials (RCTs) show mixed results – in athletes with confirmed deficiency, supplementation improves outcomes like jump height or sprint time, while in replete individuals no additional performance benefit is seen. The MyBody-X test measures 25-OH vitamin D as a screening tool, but it has limitations: it is a single time-point measurement subject to seasonal variation and cannot determine causes or guide dosing. Self-interpretation without medical supervision is not recommended, as overdosing (hypercalcemia) carries risks. The evidence for the test itself is classified as 'practice' – it provides orientation, not diagnosis. For a sports medicine evaluation, additional factors such as training status, sun exposure, and individual genetics (e.g., VDR polymorphisms) should be considered. In summary, vitamin D testing is useful for at-risk groups (e.g., indoor athletes, winter season), but the evidence for performance enhancement in those with normal levels is weak.","area":"gesundheit","canonical_id":"gesundheit:canonical-304ddc44935bc2f074f940ab","id":"public-7050577a12c5028a516c94fb","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D 25-OH in the context of Sport","score":17.44271699,"snippet":"Measuring 25-hydroxyvitamin D (25-OH vitamin D) in the context of sport is relevant because vitamin D is critical for bone health, muscle function, immune defense, and inflammation regulation. Deficiency can impair recovery, increase injury risk, and reduce performance. The evidence is nuanced: observational studies link low vitamin D levels with reduced muscle strength and higher infection rates. Randomized controlled trials (RCTs) show mixed results – in athletes with confirmed deficiency, supplementation improves outcomes like jump height or sprint time, while in replete individuals no additional performance benefit is seen. The MyBody-X test measures 25-OH vitamin D as a screening tool, ","sources":[],"title":"Evidence check: Vitamin D 25-OH in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-7050577a12c5028a516c94fb/evidence-check-vitamin-d-25-oh-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"VKORC1 (vitamin K epoxide reductase complex subunit 1) is a key gene in the vitamin K cycle, regulating the activation of clotting factors and bone matrix proteins. In a sports context, it is discussed mainly regarding bone health and fracture risk – certain variants (e.g., rs9923231) can affect vitamin K-dependent carboxylation of osteocalcin, thereby modulating bone mineral density. The evidence is largely mechanistic, coming from association studies with moderate effect sizes. Direct performance relevance (e.g., endurance, strength) is not established. Moreover, VKORC1 is a classic pharmacogene – its variants determine warfarin dosing, which may be relevant for athletes on anticoagulation but not for healthy recreational sports. Inclusion in consumer DNA tests is often driven by pharmacogenetic interest, not sports medicine indication. Conclusion: The evidence for sports relevance is weak to moderate; any interpretation should clearly state the limitations of association data.","area":"gesundheit","canonical_id":"gesundheit:canonical-1b2198287fd6ed75867c19f9","id":"public-fc6f7a041de4a408b0c4540c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: VKORC1 in the context of Sport","score":17.44006168,"snippet":"VKORC1 (vitamin K epoxide reductase complex subunit 1) is a key gene in the vitamin K cycle, regulating the activation of clotting factors and bone matrix proteins. In a sports context, it is discussed mainly regarding bone health and fracture risk – certain variants (e.g., rs9923231) can affect vitamin K-dependent carboxylation of osteocalcin, thereby modulating bone mineral density. The evidence is largely mechanistic, coming from association studies with moderate effect sizes. Direct performance relevance (e.g., endurance, strength) is not established. Moreover, VKORC1 is a classic pharmacogene – its variants determine warfarin dosing, which may be relevant for athletes on anticoagulation","sources":[],"title":"Evidence check: VKORC1 in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-fc6f7a041de4a408b0c4540c/evidence-check-vkorc1-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"A nutrient check in the context of sports can provide insights into potential deficiencies or excesses, but interpretation requires caution. Evidence for routine blood testing in healthy athletes is limited: single measurements are affected by diurnal variation, diet, and training status. Water-soluble vitamins like B vitamins are generally excreted when in excess, but high doses of B6 (>100 mg/day) can cause nerve damage, and niacin can harm the liver. The products mentioned in the context (e.g., Hormon & VitalCheck) are marketed as lifestyle tests, not diagnostic tools. For athletes, specific nutrient needs (e.g., iron, magnesium, vitamin D) can be assessed via targeted lab work, but results need clinical context and repeat measurements. DNA-based nutrient tests (e.g., MTHFR) have weak predictive power. Conclusion: A nutrient check can be useful if there is a justified suspicion of deficiency, but it does not replace medical advice. Evidence level: practice (based on guidelines, but with limitations).","area":"gesundheit","canonical_id":"gesundheit:canonical-c790c336625141d8393384bb","id":"public-4bae655251010b4bda77c37f","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Nährstoffcheck in the context of Sport","score":17.38440179,"snippet":"A nutrient check in the context of sports can provide insights into potential deficiencies or excesses, but interpretation requires caution. Evidence for routine blood testing in healthy athletes is limited: single measurements are affected by diurnal variation, diet, and training status. Water-soluble vitamins like B vitamins are generally excreted when in excess, but high doses of B6 (>100 mg/day) can cause nerve damage, and niacin can harm the liver. The products mentioned in the context (e.g., Hormon & VitalCheck) are marketed as lifestyle tests, not diagnostic tools. For athletes, specific nutrient needs (e.g., iron, magnesium, vitamin D) can be assessed via targeted lab work, but resul","sources":[],"title":"Evidence check: Nährstoffcheck in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-4bae655251010b4bda77c37f/evidence-check-naehrstoffcheck-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Folic acid (vitamin B9) is crucial for DNA synthesis, red blood cell production, and homocysteine metabolism. In sports, it is often linked to improved oxygen delivery and recovery. Evidence is moderate: some studies show benefits for endurance athletes with low baseline folate, but no consistent performance enhancement in well-nourished individuals. High doses can mask vitamin B12 deficiency, potentially leading to neurological issues. Therefore, testing folate status (e.g., serum folate, homocysteine) before supplementation is recommended. Most research focuses on endurance sports; data for strength or team sports are limited. Caveat: supplemental folic acid differs from natural food folate, and genetic variants (e.g., MTHFR) can affect conversion. Routine supplementation without confirmed deficiency is not evidence-based.","area":"gesundheit","canonical_id":"gesundheit:canonical-556d2e007aad6b9f15eda430","id":"public-e84ce9e9d2a0766dbc95f90f","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Folsäure in the context of Sport","score":17.34763513,"snippet":"Folic acid (vitamin B9) is crucial for DNA synthesis, red blood cell production, and homocysteine metabolism. In sports, it is often linked to improved oxygen delivery and recovery. Evidence is moderate: some studies show benefits for endurance athletes with low baseline folate, but no consistent performance enhancement in well-nourished individuals. High doses can mask vitamin B12 deficiency, potentially leading to neurological issues. Therefore, testing folate status (e.g., serum folate, homocysteine) before supplementation is recommended. Most research focuses on endurance sports; data for strength or team sports are limited. Caveat: supplemental folic acid differs from natural food folat","sources":[],"title":"Evidence check: Folsäure in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-e84ce9e9d2a0766dbc95f90f/evidence-check-folsaeure-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The vitamin D receptor (VDR) is often discussed in sports contexts because it influences muscle strength, bone metabolism, and immune function. Polymorphisms such as FokI (rs2228570) and BsmI (rs1544410) have been associated with differences in muscle mass, strength gains after training, and injury risk. However, the evidence is mixed: many studies are small, fail to replicate, or show only weak effects. Moreover, the impact is strongly modulated by actual vitamin D status – a genetic disadvantage can often be compensated by adequate levels. Therefore, a VDR gene test alone does not allow specific training or nutrition recommendations. It is more useful to measure serum 25(OH)-vitamin D levels. Supplementation should only be done if deficiency is confirmed, as overdosing is harmful. In the context of MyBody-X, note that their DNA tests for athletes often include markers with small effect sizes; clinical relevance is limited. In summary, VDR variants have a detectable but small influence on athletic performance parameters. The evidence does not support personalized training plans based solely on this gene.","area":"gesundheit","canonical_id":"gesundheit:canonical-4552ffb41768ae31e84b9c67","id":"public-5fb617dfae5d95add08d9a75","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: VDR in the context of Sport","score":17.26265084,"snippet":"The vitamin D receptor (VDR) is often discussed in sports contexts because it influences muscle strength, bone metabolism, and immune function. Polymorphisms such as FokI (rs2228570) and BsmI (rs1544410) have been associated with differences in muscle mass, strength gains after training, and injury risk. However, the evidence is mixed: many studies are small, fail to replicate, or show only weak effects. Moreover, the impact is strongly modulated by actual vitamin D status – a genetic disadvantage can often be compensated by adequate levels. Therefore, a VDR gene test alone does not allow specific training or nutrition recommendations. It is more useful to measure serum 25(OH)-vitamin D leve","sources":[],"title":"Evidence check: VDR in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-5fb617dfae5d95add08d9a75/evidence-check-vdr-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The provided context does not contain specific data or studies on vitamin B12 in sports. Generally, B12 is crucial for energy metabolism, red blood cell formation, and neurological function – a deficiency can impair athletic performance. However, the context lacks evidence for increased requirements in athletes or performance benefits from supplementation in non-deficient individuals. General literature shows moderate evidence: supplementation corrects deficiency-related declines, but no ergogenic effect in replete individuals. Since the context offers no sport-specific B12 research, the assessment remains conservative. Note: MyBody-X does not offer a dedicated B12 sport test; its nutrient deficiency test measures B12 but without sports interpretation. Evidence is rated as unclear.","area":"gesundheit","canonical_id":"gesundheit:canonical-cd58eb0d83ebeb69c7e725ad","id":"public-9d7e2eec061cf9d7a3453b77","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: B12 in the context of Sport","score":17.13586652,"snippet":"The provided context does not contain specific data or studies on vitamin B12 in sports. Generally, B12 is crucial for energy metabolism, red blood cell formation, and neurological function – a deficiency can impair athletic performance. However, the context lacks evidence for increased requirements in athletes or performance benefits from supplementation in non-deficient individuals. General literature shows moderate evidence: supplementation corrects deficiency-related declines, but no ergogenic effect in replete individuals. Since the context offers no sport-specific B12 research, the assessment remains conservative. Note: MyBody-X does not offer a dedicated B12 sport test; its nutrient d","sources":[],"title":"Evidence check: B12 in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-9d7e2eec061cf9d7a3453b77/evidence-check-b12-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The provided context does not contain evidence for a specific 'Cardio Risk Check' in the context of sport. MyBody-X tests cover nutrition, hormones, and microbiome, but not direct cardiovascular risk assessment for athletes. While some biomarkers (e.g., cortisol, vitamin D, omega-3 index) may influence cardiovascular health and recovery, they are not validated for predicting cardiac events during exercise. For athletes, cardiovascular screening should follow medical guidelines (e.g., ECG, echocardiogram). DTC genetic tests for heart risk have limited evidence. Therefore, the evidence for this product in a sport context is unclear and largely marketing-driven. Consumers should not rely on such tests for risk assessment and should seek medical advice.","area":"gesundheit","canonical_id":"gesundheit:canonical-2e3211391daefa869640890b","id":"public-162f0193eff83a405b740c8c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Cardio Risk Check | Herz-Kreislauf Risiko-Test in the context of Sport","score":17.12337349,"snippet":"The provided context does not contain evidence for a specific 'Cardio Risk Check' in the context of sport. MyBody-X tests cover nutrition, hormones, and microbiome, but not direct cardiovascular risk assessment for athletes. While some biomarkers (e.g., cortisol, vitamin D, omega-3 index) may influence cardiovascular health and recovery, they are not validated for predicting cardiac events during exercise. For athletes, cardiovascular screening should follow medical guidelines (e.g., ECG, echocardiogram). DTC genetic tests for heart risk have limited evidence. Therefore, the evidence for this product in a sport context is unclear and largely marketing-driven. Consumers should not rely on suc","sources":[],"title":"Evidence check: Cardio Risk Check | Herz-Kreislauf Risiko-Test in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-162f0193eff83a405b740c8c/evidence-check-cardio-risk-check-herz-kreislauf-risiko-test-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"A fertility check in the context of sport is not a well-established medical standard. The evidence is weak: some genetic variants (e.g., in LEPR or GPX1) may theoretically influence hormone regulation or sperm quality, but effect sizes are small and study results are inconsistent. More relevant factors include training load, nutritional status (iron, zinc, vitamin D), stress, and sleep. Direct-to-consumer tests often provide probabilistic results without clinical validation. A proper fertility check should be medically supervised and typically includes hormone panels, semen analysis, and imaging – not just DNA markers. In sports, caution is warranted: overtraining can impair fertility, but a genetic test alone does not provide reliable insight.","area":"gesundheit","canonical_id":"gesundheit:canonical-ea990909925202746a365b36","id":"public-9b82aa3e07ae5830d97b7bad","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Fertility Check in the context of Sport","score":17.11725702,"snippet":"A fertility check in the context of sport is not a well-established medical standard. The evidence is weak: some genetic variants (e.g., in LEPR or GPX1) may theoretically influence hormone regulation or sperm quality, but effect sizes are small and study results are inconsistent. More relevant factors include training load, nutritional status (iron, zinc, vitamin D), stress, and sleep. Direct-to-consumer tests often provide probabilistic results without clinical validation. A proper fertility check should be medically supervised and typically includes hormone panels, semen analysis, and imaging – not just DNA markers. In sports, caution is warranted: overtraining can impair fertility, but a","sources":[],"title":"Evidence check: Fertility Check in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-9b82aa3e07ae5830d97b7bad/evidence-check-fertility-check-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Insulin is a key regulator of carbohydrate metabolism during exercise. During physical activity, insulin secretion decreases to allow hepatic glucose release, while muscle cells become more sensitive to insulin, facilitating glucose uptake. Regular endurance training improves insulin sensitivity long-term, a cornerstone for preventing type 2 diabetes. The provided contexts (VO₂max, blood testing, vitamin D, fitness DNA) do not directly address insulin, but they indirectly support metabolic benefits of exercise. For instance, the VO₂max study links higher fitness to lower mortality, partly mediated by improved insulin sensitivity. The vitamin D article mentions metabolic boosting without naming insulin. Importantly, acute insulin spikes after high-carb meals can temporarily inhibit fat oxidation during exercise, making nutrient timing relevant. For athletes with insulin resistance or diabetes, individualized insulin dosing and carbohydrate management are critical. In summary, the insulin–exercise relationship is well-established in physiology, but the provided sources lack specific evidence on this topic. The evidence level is therefore based on general human physiology and clinical consensus.","area":"gesundheit","canonical_id":"gesundheit:canonical-14b82be8ce560607048e6b06","id":"public-cb8dcb8246e1e04381a20b1e","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Insulin in the context of Sport","score":17.08717215,"snippet":"Insulin is a key regulator of carbohydrate metabolism during exercise. During physical activity, insulin secretion decreases to allow hepatic glucose release, while muscle cells become more sensitive to insulin, facilitating glucose uptake. Regular endurance training improves insulin sensitivity long-term, a cornerstone for preventing type 2 diabetes. The provided contexts (VO₂max, blood testing, vitamin D, fitness DNA) do not directly address insulin, but they indirectly support metabolic benefits of exercise. For instance, the VO₂max study links higher fitness to lower mortality, partly mediated by improved insulin sensitivity. The vitamin D article mentions metabolic boosting without nami","sources":[],"title":"Evidence check: Insulin in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-cb8dcb8246e1e04381a20b1e/evidence-check-insulin-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}