{"count":10,"index":{"built_at":"2026-07-28T04:37:35.947833+00:00","public_records":55311,"revision":"b88590249a4faefc3b3c2d9a"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Vitamin D Test in the context of Haut"},"results":[{"answer":"The provided context does not contain specific data on Vitamin D 25-OH in relation to skin. Generally, vitamin D is known to play a role in skin health, including regulation of inflammation and cell proliferation. Deficiency has been associated with skin conditions like psoriasis and acne, but evidence for routine testing in healthy individuals without risk factors is limited. Measurement of 25-OH vitamin D is well-established, but its utility for skin issues alone is not supported by large randomized trials. MyBody-X offers a vitamin D test, but interpretation should consider overall health context. A single value does not directly reflect skin health, as many factors (UV exposure, diet, genetics) are involved. Evidence is rated as moderate, based on observational and mechanistic studies. Caveat: No direct sources from the provided context.","area":"gesundheit","canonical_id":"gesundheit:canonical-0129610150b6328861c4a02c","id":"public-03d39a2527c7f57dcf39990a","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D 25-OH in the context of Haut","score":16.47953131,"snippet":"The provided context does not contain specific data on Vitamin D 25-OH in relation to skin. Generally, vitamin D is known to play a role in skin health, including regulation of inflammation and cell proliferation. Deficiency has been associated with skin conditions like psoriasis and acne, but evidence for routine testing in healthy individuals without risk factors is limited. Measurement of 25-OH vitamin D is well-established, but its utility for skin issues alone is not supported by large randomized trials. MyBody-X offers a vitamin D test, but interpretation should consider overall health context. A single value does not directly reflect skin health, as many factors (UV exposure, diet, ge","sources":[],"title":"Evidence check: Vitamin D 25-OH in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-03d39a2527c7f57dcf39990a/evidence-check-vitamin-d-25-oh-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"VKORC1 encodes vitamin K epoxide reductase, a key enzyme in vitamin K recycling, and is best known for its role in warfarin sensitivity. In the context of skin, evidence is sparse and indirect. Vitamin K is involved in skin health, including wound healing, anti-aging, and possibly reducing bruising, but direct links between VKORC1 variants and skin conditions such as eczema, psoriasis, or photoaging are not established. Current evidence is limited to mechanistic hypotheses and animal studies. Therefore, VKORC1 testing offers no actionable insights for skin care or dermatological conditions. The evidence level is unclear.","area":"gesundheit","canonical_id":"gesundheit:canonical-b446cc2ed19e9fadc99c5904","id":"public-fb8de9a4f2bc6efcd39a68af","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: VKORC1 in the context of Haut","score":16.42514957,"snippet":"VKORC1 encodes vitamin K epoxide reductase, a key enzyme in vitamin K recycling, and is best known for its role in warfarin sensitivity. In the context of skin, evidence is sparse and indirect. Vitamin K is involved in skin health, including wound healing, anti-aging, and possibly reducing bruising, but direct links between VKORC1 variants and skin conditions such as eczema, psoriasis, or photoaging are not established. Current evidence is limited to mechanistic hypotheses and animal studies. Therefore, VKORC1 testing offers no actionable insights for skin care or dermatological conditions. The evidence level is unclear.","sources":[],"title":"Evidence check: VKORC1 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-fb8de9a4f2bc6efcd39a68af/evidence-check-vkorc1-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Based on the available context, there is no indication that MyBody-X offers a telomere length test or an epigenetic clock test for measuring biological age. The product descriptions and knowledge database do not list such analyses. Biological age determination is a complex field typically relying on epigenetic markers (e.g., DNA methylation) or telomere length measurements – neither of which appears in MyBody-X's current offerings. Simple DNA tests claiming to predict biological age are often not scientifically validated. If you want to measure your biological age, consider specialized laboratories or clinical providers using validated methods like the Horvath clock or telomere length assays. The evidence for this answer is graded as 'unclear' because product information may be incomplete, but currently no such tests are documented.","area":"gesundheit","canonical_id":"gesundheit:canonical-a79982da64e7b2fe778f9e5d","id":"public-a105f696393c2342c4cba208","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D Test in the context of Haut","score":16.38873869,"snippet":"Based on the available context, there is no indication that MyBody-X offers a telomere length test or an epigenetic clock test for measuring biological age. The product descriptions and knowledge database do not list such analyses. Biological age determination is a complex field typically relying on epigenetic markers (e.g., DNA methylation) or telomere length measurements – neither of which appears in MyBody-X's current offerings. Simple DNA tests claiming to predict biological age are often not scientifically validated. If you want to measure your biological age, consider specialized laboratories or clinical providers using validated methods like the Horvath clock or telomere length assays","sources":[],"title":"Evidence check: Vitamin D Test in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-a105f696393c2342c4cba208/evidence-check-vitamin-d-test-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The vitamin D receptor (VDR) is frequently discussed in the context of skin health, particularly psoriasis, skin barrier function, and premature aging. The evidence is moderate: human observational studies and GWAS have linked VDR polymorphisms (e.g., FokI, TaqI) to psoriasis risk, but effect sizes are small and replication inconsistent. For direct anti-aging effects (collagen, elasticity), robust clinical trials are lacking; most data come from cell or animal models. VDR does influence keratinocyte differentiation and local vitamin D activation, which is biologically plausible, but a personalized recommendation based solely on a genetic test is not evidence-based. Caveat: Vitamin D supplementation should not be guided by a VDR test alone – blood levels of 25(OH)D are clinically more relevant. MyBody-X tests provide orienting hints, not diagnoses.","area":"gesundheit","canonical_id":"gesundheit:canonical-d586e65cefa4cf71316f9173","id":"public-e6fe4e3eb6cddc662babb181","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: VDR in the context of Haut","score":16.29418572,"snippet":"The vitamin D receptor (VDR) is frequently discussed in the context of skin health, particularly psoriasis, skin barrier function, and premature aging. The evidence is moderate: human observational studies and GWAS have linked VDR polymorphisms (e.g., FokI, TaqI) to psoriasis risk, but effect sizes are small and replication inconsistent. For direct anti-aging effects (collagen, elasticity), robust clinical trials are lacking; most data come from cell or animal models. VDR does influence keratinocyte differentiation and local vitamin D activation, which is biologically plausible, but a personalized recommendation based solely on a genetic test is not evidence-based. Caveat: Vitamin D suppleme","sources":[],"title":"Evidence check: VDR in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-e6fe4e3eb6cddc662babb181/evidence-check-vdr-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"A nutrient check in the context of skin, as offered by MyBody-X, typically analyzes DNA variants in genes like VDR (vitamin D receptor) or SOD2 (superoxide dismutase). However, the evidence for personalized dietary recommendations from such tests is weak. VDR variants have only a small effect on vitamin D metabolism, and SOD2 variants alter antioxidant capacity marginally. High-dose antioxidants are not proven beneficial and may be harmful. Skin health is far more influenced by UV exposure, diet, sleep, and skincare. MyBody-X itself rates many of these tests as 'marketing' or 'mechanistic'. A nutrient check can serve as a conversation starter for a balanced diet but does not replace medical advice. Caveat: Do not diagnose skin conditions or deficiencies from DNA alone.","area":"gesundheit","canonical_id":"gesundheit:canonical-3ae39840de8cbacc636446b0","id":"public-122729e9044b2640dfe9d463","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Nährstoffcheck in the context of Haut","score":16.19360032,"snippet":"A nutrient check in the context of skin, as offered by MyBody-X, typically analyzes DNA variants in genes like VDR (vitamin D receptor) or SOD2 (superoxide dismutase). However, the evidence for personalized dietary recommendations from such tests is weak. VDR variants have only a small effect on vitamin D metabolism, and SOD2 variants alter antioxidant capacity marginally. High-dose antioxidants are not proven beneficial and may be harmful. Skin health is far more influenced by UV exposure, diet, sleep, and skincare. MyBody-X itself rates many of these tests as 'marketing' or 'mechanistic'. A nutrient check can serve as a conversation starter for a balanced diet but does not replace medical ","sources":[],"title":"Evidence check: Nährstoffcheck in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-122729e9044b2640dfe9d463/evidence-check-naehrstoffcheck-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query concerns a DNA test called 'Fitness Vitality DNA' in the context of skin. The provided context includes only general SNP frequencies (rs1800497, rs1001179) and a brief Q&A on vitamin D and VDR. There is no direct evidence that this specific test provides clinically valid insights for skin health. Many commercial DNA tests combine markers for fitness, nutrition, and skin, but the evidence for personalized actionable recommendations is weak. Skin aging is dominated by UV exposure, lifestyle, and hormones; individual genetic variants (e.g., in collagen or antioxidant pathways) have only minor effects. The VDR SNP rs731236 may subtly influence vitamin D signaling, but its clinical relevance for skin is unclear. Without validated studies linking this test to skin parameters like elasticity, wrinkling, or acne, its predictive value remains speculative. I advise caution: such tests are often marketing, not medicine. A dermatologist or blood analysis (e.g., vitamin D, ferritin) is more reliable.","area":"gesundheit","canonical_id":"gesundheit:canonical-70e65a995c3ff618d62e209c","id":"public-5137637d391de53b4854755d","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Fitness Vitality DNA in the context of Haut","score":16.17991001,"snippet":"The query concerns a DNA test called 'Fitness Vitality DNA' in the context of skin. The provided context includes only general SNP frequencies (rs1800497, rs1001179) and a brief Q&A on vitamin D and VDR. There is no direct evidence that this specific test provides clinically valid insights for skin health. Many commercial DNA tests combine markers for fitness, nutrition, and skin, but the evidence for personalized actionable recommendations is weak. Skin aging is dominated by UV exposure, lifestyle, and hormones; individual genetic variants (e.g., in collagen or antioxidant pathways) have only minor effects. The VDR SNP rs731236 may subtly influence vitamin D signaling, but its clinical rele","sources":[],"title":"Evidence check: Fitness Vitality DNA in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-5137637d391de53b4854755d/evidence-check-fitness-vitality-dna-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Folic acid (vitamin B9) is crucial for cell division and skin renewal. The provided context does not directly address skin, but includes general folate metabolism (MTHFR 677T, PMID 26497154). Observational studies suggest folic acid may support UV protection and wound healing, but the evidence is moderate and insufficient for specific skin recommendations. High doses (>1000 mcg/day) should be avoided, especially with MTHFR variants. For skin concerns, consult a doctor. Genetic testing for MTHFR provides only partial insight; environmental and dietary factors are more influential.","area":"gesundheit","canonical_id":"gesundheit:canonical-1e5ff0f40d4e32e192e41ffb","id":"public-315089aa669188a257d4f9d5","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Folsäure in the context of Haut","score":16.05708484,"snippet":"Folic acid (vitamin B9) is crucial for cell division and skin renewal. The provided context does not directly address skin, but includes general folate metabolism (MTHFR 677T, PMID 26497154). Observational studies suggest folic acid may support UV protection and wound healing, but the evidence is moderate and insufficient for specific skin recommendations. High doses (>1000 mcg/day) should be avoided, especially with MTHFR variants. For skin concerns, consult a doctor. Genetic testing for MTHFR provides only partial insight; environmental and dietary factors are more influential.","sources":[],"title":"Evidence check: Folsäure in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-315089aa669188a257d4f9d5/evidence-check-folsaeure-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query asks about a 'Cardio Risk Check' in the context of 'Haut' (skin) – possibly a product or combination of cardiovascular and skin analysis. However, the provided context contains no specific test or scientific evidence for such a check. The available information covers other MyBody-X products like the Vitamin-D self-test, Menopause Check, or DNA diet tests, whose evidence is rated as 'marketing/unclear'. A cardio risk screening based on skin parameters is not scientifically established. Classic cardiovascular risk factors (blood pressure, cholesterol, smoking, diabetes, genetics) are not measured via skin. While certain skin changes (e.g., xanthelasmas) can indicate lipid disorders, a direct 'Cardio Risk Check' via skin tests is speculative. MyBody-X currently does not appear to offer such a test. Consumers should rely on validated medical screenings. The evidence for a combined skin-cardio test is unclear and unsupported by the provided sources. Caution against exaggerated marketing claims is warranted.","area":"gesundheit","canonical_id":"gesundheit:canonical-25b83e033cba53039aacd4a8","id":"public-03ce04b653303f0b216f24d8","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Cardio Risk Check in the context of Haut","score":15.91690338,"snippet":"The query asks about a 'Cardio Risk Check' in the context of 'Haut' (skin) – possibly a product or combination of cardiovascular and skin analysis. However, the provided context contains no specific test or scientific evidence for such a check. The available information covers other MyBody-X products like the Vitamin-D self-test, Menopause Check, or DNA diet tests, whose evidence is rated as 'marketing/unclear'. A cardio risk screening based on skin parameters is not scientifically established. Classic cardiovascular risk factors (blood pressure, cholesterol, smoking, diabetes, genetics) are not measured via skin. While certain skin changes (e.g., xanthelasmas) can indicate lipid disorders, ","sources":[],"title":"Evidence check: Cardio Risk Check in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-03ce04b653303f0b216f24d8/evidence-check-cardio-risk-check-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"ApoB (apolipoprotein B) is a key component of atherogenic lipoproteins and is primarily used for cardiovascular risk assessment. A direct link between ApoB and skin health is not well established in the scientific literature. There is mechanistic evidence that oxidized lipoproteins may contribute to skin aging, but robust clinical studies are lacking. MyBody-X does not include ApoB in its current test panels; for skin concerns such as acne or premature aging, other biomarkers (e.g., inflammatory markers, vitamin D) or lifestyle factors are more relevant. The evidence for ApoB in this context is best described as 'mechanistic' or 'unclear'. Consult a physician for specific skin issues.","area":"gesundheit","canonical_id":"gesundheit:canonical-481d7303c990ab348f37e567","id":"public-659929e0b75bbc5f1f2f6a80","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: ApoB in the context of Haut","score":15.88029512,"snippet":"ApoB (apolipoprotein B) is a key component of atherogenic lipoproteins and is primarily used for cardiovascular risk assessment. A direct link between ApoB and skin health is not well established in the scientific literature. There is mechanistic evidence that oxidized lipoproteins may contribute to skin aging, but robust clinical studies are lacking. MyBody-X does not include ApoB in its current test panels; for skin concerns such as acne or premature aging, other biomarkers (e.g., inflammatory markers, vitamin D) or lifestyle factors are more relevant. The evidence for ApoB in this context is best described as 'mechanistic' or 'unclear'. Consult a physician for specific skin issues.","sources":[],"title":"Evidence check: ApoB in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-659929e0b75bbc5f1f2f6a80/evidence-check-apob-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query concerns a 'Cardio Risk Check' (cardiovascular risk test) in the context of 'skin'. The provided context does not contain direct evidence for such a test. Fragments (MELK gene, TRH gene, lactose intolerance, iron/ferritin self-test) are only loosely related to cardiovascular risk. The MELK gene note on vitamin K epoxide reductase is mechanistic and unclear; the TRH gene entry involves the thyroid axis, which can indirectly affect the cardiovascular system but is not a risk screening tool. The iron/ferritin test is a lifestyle product without cardiovascular validation. Skin signs such as xanthelasmas or arcus lipoides corneae are clinical markers of lipid disorders but are not typically assessed by DTC genetic tests. The evidence for a 'Cardio Risk Check' as a skin-related test is weak and based on mechanistic assumptions. Consumers should not rely on such tests for medical decisions; a clinical lipid panel and physician risk assessment are necessary.","area":"gesundheit","canonical_id":"gesundheit:canonical-8e1a2a90bf259a86f08d8130","id":"public-2255df62d7f18aec6f94f765","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Cardio Risk Check | Herz-Kreislauf Risiko-Test in the context of Haut","score":15.7954988,"snippet":"The query concerns a 'Cardio Risk Check' (cardiovascular risk test) in the context of 'skin'. The provided context does not contain direct evidence for such a test. Fragments (MELK gene, TRH gene, lactose intolerance, iron/ferritin self-test) are only loosely related to cardiovascular risk. The MELK gene note on vitamin K epoxide reductase is mechanistic and unclear; the TRH gene entry involves the thyroid axis, which can indirectly affect the cardiovascular system but is not a risk screening tool. The iron/ferritin test is a lifestyle product without cardiovascular validation. Skin signs such as xanthelasmas or arcus lipoides corneae are clinical markers of lipid disorders but are not typic","sources":[],"title":"Evidence check: Cardio Risk Check | Herz-Kreislauf Risiko-Test in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-2255df62d7f18aec6f94f765/evidence-check-cardio-risk-check-herz-kreislauf-risiko-test-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}