{"count":2,"index":{"built_at":"2026-07-27T22:10:21.749464+00:00","public_records":55311,"revision":"f4e80df10aa0632a269ebe12"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Vitamin D 25-OH in the context of skin aging"},"results":[{"answer":"The provided context contains no direct information on Vitamin D 25-OH and skin aging. In general, vitamin D is synthesized in skin upon UVB exposure and has immunomodulatory and anti-proliferative properties. Some observational studies link low 25-hydroxyvitamin D levels with signs of skin aging such as reduced elasticity and wrinkling, but the evidence is largely associative, not causal. MyBody-X may offer a vitamin D blood test, but this is not mentioned in the context. A single 25-OH measurement cannot reliably predict skin aging due to confounding factors like sun exposure, genetics, and diet. Evidence: mechanistic/observational, insufficient for precise anti-aging guidance. Caveat: not a diagnostic tool; consult a physician for deficiency.","area":"gesundheit","canonical_id":"gesundheit:canonical-91c76081a00527e9ff34057b","id":"public-803eb276e3a29184d3c13d86","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D 25-OH in the context of skin aging","score":32.4798951,"snippet":"The provided context contains no direct information on Vitamin D 25-OH and skin aging. In general, vitamin D is synthesized in skin upon UVB exposure and has immunomodulatory and anti-proliferative properties. Some observational studies link low 25-hydroxyvitamin D levels with signs of skin aging such as reduced elasticity and wrinkling, but the evidence is largely associative, not causal. MyBody-X may offer a vitamin D blood test, but this is not mentioned in the context. A single 25-OH measurement cannot reliably predict skin aging due to confounding factors like sun exposure, genetics, and diet. Evidence: mechanistic/observational, insufficient for precise anti-aging guidance. Caveat: not","sources":[],"title":"Evidence check: Vitamin D 25-OH in the context of skin aging","url":"https://tikki.wiki/wissen/gesundheit/frage/public-803eb276e3a29184d3c13d86/evidence-check-vitamin-d-25-oh-in-the-context-of-skin-aging/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The vitamin D receptor (VDR) is frequently discussed in the context of skin health, particularly psoriasis, skin barrier function, and premature aging. The evidence is moderate: human observational studies and GWAS have linked VDR polymorphisms (e.g., FokI, TaqI) to psoriasis risk, but effect sizes are small and replication inconsistent. For direct anti-aging effects (collagen, elasticity), robust clinical trials are lacking; most data come from cell or animal models. VDR does influence keratinocyte differentiation and local vitamin D activation, which is biologically plausible, but a personalized recommendation based solely on a genetic test is not evidence-based. Caveat: Vitamin D supplementation should not be guided by a VDR test alone – blood levels of 25(OH)D are clinically more relevant. MyBody-X tests provide orienting hints, not diagnoses.","area":"gesundheit","canonical_id":"gesundheit:canonical-d586e65cefa4cf71316f9173","id":"public-e6fe4e3eb6cddc662babb181","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: VDR in the context of Haut","score":28.67950568,"snippet":"The vitamin D receptor (VDR) is frequently discussed in the context of skin health, particularly psoriasis, skin barrier function, and premature aging. The evidence is moderate: human observational studies and GWAS have linked VDR polymorphisms (e.g., FokI, TaqI) to psoriasis risk, but effect sizes are small and replication inconsistent. For direct anti-aging effects (collagen, elasticity), robust clinical trials are lacking; most data come from cell or animal models. VDR does influence keratinocyte differentiation and local vitamin D activation, which is biologically plausible, but a personalized recommendation based solely on a genetic test is not evidence-based. Caveat: Vitamin D suppleme","sources":[],"title":"Evidence check: VDR in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-e6fe4e3eb6cddc662babb181/evidence-check-vdr-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}