{"count":2,"index":{"built_at":"2026-07-28T05:08:57.052966+00:00","public_records":55311,"revision":"fd0670adc3eff979f8872f84"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Vitamin D 25-OH in the context of fatigue"},"results":[{"answer":"The relationship between vitamin D 25-OH levels and fatigue is not clearly established. Observational studies suggest an association between low vitamin D (< 12 ng/ml) and increased fatigue, but randomized controlled trials have not consistently shown that supplementation reduces fatigue in the general population. The evidence is moderate: deficiency may contribute to fatigue, but it is rarely the sole cause. Other factors such as sleep quality, stress, iron deficiency, or thyroid function are often more significant. Testing vitamin D in the context of fatigue can be reasonable, but results should be interpreted with caution and ideally by a physician. Supplementation without confirmed deficiency is not supported by strong evidence. Overall, while low vitamin D is a plausible contributor, it is not a proven independent cause of fatigue.","area":"gesundheit","canonical_id":"gesundheit:canonical-bc1332e2f34b34166419858b","id":"public-3b5e3a254c6225c4a1ae7574","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D 25-OH in the context of fatigue","score":26.16343479,"snippet":"The relationship between vitamin D 25-OH levels and fatigue is not clearly established. Observational studies suggest an association between low vitamin D (< 12 ng/ml) and increased fatigue, but randomized controlled trials have not consistently shown that supplementation reduces fatigue in the general population. The evidence is moderate: deficiency may contribute to fatigue, but it is rarely the sole cause. Other factors such as sleep quality, stress, iron deficiency, or thyroid function are often more significant. Testing vitamin D in the context of fatigue can be reasonable, but results should be interpreted with caution and ideally by a physician. Supplementation without confirmed defic","sources":[],"title":"Evidence check: Vitamin D 25-OH in the context of fatigue","url":"https://tikki.wiki/wissen/gesundheit/frage/public-3b5e3a254c6225c4a1ae7574/evidence-check-vitamin-d-25-oh-in-the-context-of-fatigue/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The link between vitamin D (25-OH) and fatigue is clinically plausible but evidence is nuanced. Epidemiological studies consistently associate low serum 25-hydroxyvitamin D (<20 ng/mL) with increased fatigue, muscle weakness, and reduced physical performance. However, randomized controlled trials (RCTs) show a clear benefit of supplementation on fatigue only in individuals with baseline deficiency. In replete individuals (>30 ng/mL), additional vitamin D does not reliably improve fatigue. Fatigue is a multifactorial symptom; causes include iron deficiency, thyroid dysfunction, sleep disorders, and depression. A single vitamin D test without comprehensive workup is insufficient. MyBody-X offers blood-based vitamin D measurement, but results should be interpreted by a clinician. Caveat: Self-diagnosis and supplementation based solely on a lab value can be misleading and potentially harmful (e.g., toxicity with excessive intake). Evidence: human-moderate (predominantly observational, some RCTs).","area":"gesundheit","canonical_id":"gesundheit:canonical-d20e080e99671d4d6243b3c1","id":"public-4740a65d1661f7712720279b","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Vitamin D 25-OH in the context of Müdigkeit","score":25.92625125,"snippet":"The link between vitamin D (25-OH) and fatigue is clinically plausible but evidence is nuanced. Epidemiological studies consistently associate low serum 25-hydroxyvitamin D (<20 ng/mL) with increased fatigue, muscle weakness, and reduced physical performance. However, randomized controlled trials (RCTs) show a clear benefit of supplementation on fatigue only in individuals with baseline deficiency. In replete individuals (>30 ng/mL), additional vitamin D does not reliably improve fatigue. Fatigue is a multifactorial symptom; causes include iron deficiency, thyroid dysfunction, sleep disorders, and depression. A single vitamin D test without comprehensive workup is insufficient. MyBody-X offe","sources":[],"title":"Evidence check: Vitamin D 25-OH in the context of Müdigkeit","url":"https://tikki.wiki/wissen/gesundheit/frage/public-4740a65d1661f7712720279b/evidence-check-vitamin-d-25-oh-in-the-context-of-muedigkeit/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}