{"count":2,"index":{"built_at":"2026-07-27T20:15:32.749673+00:00","public_records":55311,"revision":"99ca9a64a893eed138b4a14e"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: VKORC1 in the context of Sport"},"results":[{"answer":"VKORC1 (vitamin K epoxide reductase complex subunit 1) is a key gene in the vitamin K cycle, regulating the activation of clotting factors and bone matrix proteins. In a sports context, it is discussed mainly regarding bone health and fracture risk – certain variants (e.g., rs9923231) can affect vitamin K-dependent carboxylation of osteocalcin, thereby modulating bone mineral density. The evidence is largely mechanistic, coming from association studies with moderate effect sizes. Direct performance relevance (e.g., endurance, strength) is not established. Moreover, VKORC1 is a classic pharmacogene – its variants determine warfarin dosing, which may be relevant for athletes on anticoagulation but not for healthy recreational sports. Inclusion in consumer DNA tests is often driven by pharmacogenetic interest, not sports medicine indication. Conclusion: The evidence for sports relevance is weak to moderate; any interpretation should clearly state the limitations of association data.","area":"gesundheit","canonical_id":"gesundheit:canonical-1b2198287fd6ed75867c19f9","id":"public-fc6f7a041de4a408b0c4540c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: VKORC1 in the context of Sport","score":24.61397326,"snippet":"VKORC1 (vitamin K epoxide reductase complex subunit 1) is a key gene in the vitamin K cycle, regulating the activation of clotting factors and bone matrix proteins. In a sports context, it is discussed mainly regarding bone health and fracture risk – certain variants (e.g., rs9923231) can affect vitamin K-dependent carboxylation of osteocalcin, thereby modulating bone mineral density. The evidence is largely mechanistic, coming from association studies with moderate effect sizes. Direct performance relevance (e.g., endurance, strength) is not established. Moreover, VKORC1 is a classic pharmacogene – its variants determine warfarin dosing, which may be relevant for athletes on anticoagulation","sources":[],"title":"Evidence check: VKORC1 in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-fc6f7a041de4a408b0c4540c/evidence-check-vkorc1-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The evidence for pharmacogenetic testing in sports is mixed. While certain gene variants (e.g., CYP2D6, CYP2C9, VKORC1) can influence the metabolism of drugs like NSAIDs, beta-blockers, or caffeine, there is a lack of specific studies demonstrating a direct performance benefit or safety risk for athletes. Most findings come from clinical pharmacogenetics and have not been systematically validated in athletic populations. Additionally, many tested variants are population-specific and often have only moderate effect sizes. A standalone DNA test without accompanying blood level measurements or medical history can be misleading. In elite sports, doping regulations must also be considered – a genetic predisposition does not justify substance use outside permitted medication. Conclusion: Pharmacogenetics in sports is an emerging field, but current evidence does not support routine recommendations. A test may serve as supplementary information but should never be the sole basis for medication decisions.","area":"gesundheit","canonical_id":"gesundheit:canonical-175c57d040265239e365118e","id":"public-9c0799a781ab3cc4b6337b37","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Pharmakogenetik Medicheck in the context of Sport","score":22.4150328,"snippet":"The evidence for pharmacogenetic testing in sports is mixed. While certain gene variants (e.g., CYP2D6, CYP2C9, VKORC1) can influence the metabolism of drugs like NSAIDs, beta-blockers, or caffeine, there is a lack of specific studies demonstrating a direct performance benefit or safety risk for athletes. Most findings come from clinical pharmacogenetics and have not been systematically validated in athletic populations. Additionally, many tested variants are population-specific and often have only moderate effect sizes. A standalone DNA test without accompanying blood level measurements or medical history can be misleading. In elite sports, doping regulations must also be considered – a gen","sources":[],"title":"Evidence check: Pharmakogenetik Medicheck in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-9c0799a781ab3cc4b6337b37/evidence-check-pharmakogenetik-medicheck-in-the-context-of-sport/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}