{"count":10,"index":{"built_at":"2026-07-28T19:19:10.733897+00:00","public_records":70263,"revision":"4db6d26b3c449255bf596dd5"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Progesteron in the context of sleep"},"results":[{"answer":"Progesterone is frequently discussed in the context of sleep, especially for perimenopausal women. Its metabolite allopregnanolone acts as a positive allosteric modulator of GABA-A receptors, promoting sleep onset. Randomized controlled trials indicate that oral progesterone can reduce sleep latency and improve subjective sleep quality. However, effects are modest and depend on baseline hormone levels. Evidence is weaker for men or women with normal progesterone. Side effects like dizziness or mood changes may occur. Overall evidence is human-moderate: there are well-designed studies, but not enough to support broad recommendations. Direct-to-consumer progesterone tests are not diagnostic and should not guide self-treatment. Clinical assessment with blood testing is necessary before any hormone therapy.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-79b390b59e2f9798bbc09c82","id":"public-eb81d6c175d311f7516780be","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Progesteron in the context of sleep","research_origin_label":"","score":23.60041434,"snippet":"Progesterone is frequently discussed in the context of sleep, especially for perimenopausal women. Its metabolite allopregnanolone acts as a positive allosteric modulator of GABA-A receptors, promoting sleep onset. Randomized controlled trials indicate that oral progesterone can reduce sleep latency and improve subjective sleep quality. However, effects are modest and depend on baseline hormone levels. Evidence is weaker for men or women with normal progesterone. Side effects like dizziness or mood changes may occur. Overall evidence is human-moderate: there are well-designed studies, but not enough to support broad recommendations. Direct-to-consumer progesterone tests are not diagnostic an","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Progesteron in the context of sleep","url":"https://tikki.wiki/wissen/gesundheit/frage/public-eb81d6c175d311f7516780be/evidence-check-progesteron-in-the-context-of-sleep/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Progesterone is known to have sleep-promoting effects, primarily through its action on GABA-A receptors, similar to benzodiazepines. It can reduce sleep onset latency and increase slow-wave sleep, especially in women during the luteal phase. However, the evidence is mixed: while some studies show benefits for sleep quality, large randomized controlled trials are lacking. Effects are dose-dependent and vary individually. In men or postmenopausal women without hormone deficiency, the impact is less clear. Progesterone as a supplement or hormone therapy should only be used under medical supervision due to potential side effects like drowsiness, dizziness, or mood changes. The provided context does not include specific studies on progesterone and sleep, so this assessment is based on general physiological and clinical knowledge. Evidence grade: human-moderate.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-df339387dee502916b2857f0","id":"public-65907e7596648e7bf7f7e95e","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Progesteron in the context of Schlaf","research_origin_label":"","score":23.34329283,"snippet":"Progesterone is known to have sleep-promoting effects, primarily through its action on GABA-A receptors, similar to benzodiazepines. It can reduce sleep onset latency and increase slow-wave sleep, especially in women during the luteal phase. However, the evidence is mixed: while some studies show benefits for sleep quality, large randomized controlled trials are lacking. Effects are dose-dependent and vary individually. In men or postmenopausal women without hormone deficiency, the impact is less clear. Progesterone as a supplement or hormone therapy should only be used under medical supervision due to potential side effects like drowsiness, dizziness, or mood changes. The provided context d","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Progesteron in the context of Schlaf","url":"https://tikki.wiki/wissen/gesundheit/frage/public-65907e7596648e7bf7f7e95e/evidence-check-progesteron-in-the-context-of-schlaf/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Progesterone is often linked to fatigue, especially during the menstrual cycle or perimenopause. In the luteal phase, rising progesterone and its metabolite allopregnanolone modulate GABA receptors, producing sedative effects. Some women experience fatigue, while others report sleep disruption. The evidence is mostly mechanistic and observational; clinical trials directly linking progesterone to fatigue are limited. Deficiency or excess can affect energy, but individual responses vary widely. The provided context contains no specific studies on progesterone and fatigue. Thus, any evidence-based claim is weak. For persistent fatigue, other causes (thyroid, iron deficiency, sleep apnea) should be ruled out. Hormone testing without medical indication often leads to overinterpretation. Evidence rating: mechanistic/practice, no strong human study in context.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-b51d5c2bf43f3ad5cc43ddca","id":"public-5ba3100a40e5ff83e36304db","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Progesteron in the context of fatigue","research_origin_label":"","score":23.1227081,"snippet":"Progesterone is often linked to fatigue, especially during the menstrual cycle or perimenopause. In the luteal phase, rising progesterone and its metabolite allopregnanolone modulate GABA receptors, producing sedative effects. Some women experience fatigue, while others report sleep disruption. The evidence is mostly mechanistic and observational; clinical trials directly linking progesterone to fatigue are limited. Deficiency or excess can affect energy, but individual responses vary widely. The provided context contains no specific studies on progesterone and fatigue. Thus, any evidence-based claim is weak. For persistent fatigue, other causes (thyroid, iron deficiency, sleep apnea) should","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Progesteron in the context of fatigue","url":"https://tikki.wiki/wissen/gesundheit/frage/public-5ba3100a40e5ff83e36304db/evidence-check-progesteron-in-the-context-of-fatigue/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Progesterone plays a key role in menopause, as its natural decline contributes to symptoms like sleep disturbances, mood swings, and irregular bleeding. Hormone replacement therapy (HRT) with progesterone (often combined with estrogen) is evidence-based and recommended by guidelines (e.g., from the North American Menopause Society) to alleviate symptoms and protect the endometrium. However, the provided context lacks specific information on progesterone testing from MyBody-X. A standalone progesterone blood test can measure levels, but it is not diagnostic on its own – interpretation requires cycle timing (in premenopausal women) or clinical context. Consumer tests offer insights, not diagnoses; medical evaluation is essential for menopause management. The evidence for progesterone's role in menopause is strong (randomized trials, meta-analyses), but single measurements are unreliable. Caution: self-administration of progesterone carries risks and should only be done under medical supervision.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-909e497f7322a3e757aedcca","id":"public-c3104ad1cb341f59d3bdb630","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Progesteron in the context of menopause","research_origin_label":"","score":22.46330366,"snippet":"Progesterone plays a key role in menopause, as its natural decline contributes to symptoms like sleep disturbances, mood swings, and irregular bleeding. Hormone replacement therapy (HRT) with progesterone (often combined with estrogen) is evidence-based and recommended by guidelines (e.g., from the North American Menopause Society) to alleviate symptoms and protect the endometrium. However, the provided context lacks specific information on progesterone testing from MyBody-X. A standalone progesterone blood test can measure levels, but it is not diagnostic on its own – interpretation requires cycle timing (in premenopausal women) or clinical context. Consumer tests offer insights, not diagno","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Progesteron in the context of menopause","url":"https://tikki.wiki/wissen/gesundheit/frage/public-c3104ad1cb341f59d3bdb630/evidence-check-progesteron-in-the-context-of-menopause/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Progesterone is commonly used in menopause as part of hormone replacement therapy (HRT), primarily combined with estrogen to reduce endometrial hyperplasia risk. Evidence for relief of hot flashes and sleep disturbances is moderate, mostly from observational studies and clinical practice. Recent research suggests benefits for bone density and cognitive function, but results are mixed. Crucially, individual risk-benefit assessment is essential, as progesterone can cause side effects like mood swings or fatigue. Use should always be medically supervised. Genetic testing for progesterone receptor variants (e.g., PGR) is not currently validated for clinical decision-making. The overall evidence level is 'human-moderate' due to limited randomized controlled trials. Consumers should not rely solely on DNA tests but seek professional medical advice.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-a060ff17424752d659e16966","id":"public-0f0e3ef2491abb6a31dd1114","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Progesteron in the context of Wechseljahre","research_origin_label":"","score":22.43448346,"snippet":"Progesterone is commonly used in menopause as part of hormone replacement therapy (HRT), primarily combined with estrogen to reduce endometrial hyperplasia risk. Evidence for relief of hot flashes and sleep disturbances is moderate, mostly from observational studies and clinical practice. Recent research suggests benefits for bone density and cognitive function, but results are mixed. Crucially, individual risk-benefit assessment is essential, as progesterone can cause side effects like mood swings or fatigue. Use should always be medically supervised. Genetic testing for progesterone receptor variants (e.g., PGR) is not currently validated for clinical decision-making. The overall evidence ","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Progesteron in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-0f0e3ef2491abb6a31dd1114/evidence-check-progesteron-in-the-context-of-wechseljahre/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The question about progesterone and fatigue is clinically relevant, but the provided context contains no direct studies or genetic markers on this topic. It is well known that progesterone – especially during the luteal phase, pregnancy, or with exogenous intake (e.g., hormone therapy) – can have sedative effects via its metabolites (e.g., allopregnanolone) acting on GABA receptors, potentially causing fatigue. The evidence is based on physiological and observational studies (human-moderate). However, a genetic test for receptor variants (e.g., PGR, NR3C1) cannot reliably predict individual sensitivity. The context snippets on NR3C1 and other genes consistently emphasize small effect sizes and lack of clinical validation. Therefore, hormone measurement (saliva/blood) is more informative than DNA testing. MyBody-X offers hormone tests, but interpretation must consider the whole picture – fatigue has many causes (sleep, stress, nutrition, thyroid). Beware of marketing that presents DNA results as a standalone explanation for fatigue.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-3e2c817b49c76b1f6f43e6a8","id":"public-12015250d36c69588f7e54af","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Progesteron in the context of Müdigkeit","research_origin_label":"","score":21.95228159,"snippet":"The question about progesterone and fatigue is clinically relevant, but the provided context contains no direct studies or genetic markers on this topic. It is well known that progesterone – especially during the luteal phase, pregnancy, or with exogenous intake (e.g., hormone therapy) – can have sedative effects via its metabolites (e.g., allopregnanolone) acting on GABA receptors, potentially causing fatigue. The evidence is based on physiological and observational studies (human-moderate). However, a genetic test for receptor variants (e.g., PGR, NR3C1) cannot reliably predict individual sensitivity. The context snippets on NR3C1 and other genes consistently emphasize small effect sizes a","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Progesteron in the context of Müdigkeit","url":"https://tikki.wiki/wissen/gesundheit/frage/public-12015250d36c69588f7e54af/evidence-check-progesteron-in-the-context-of-muedigkeit/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Based on the provided context, there is no direct evidence addressing whether a Menopause Check is useful for sleep. Generally, menopause can affect sleep due to hormonal changes (e.g., declining estrogen and progesterone). A Menopause Check (e.g., blood test measuring FSH, estradiol, progesterone) may provide insight into hormonal status, but evidence linking such tests to improved sleep outcomes is weak. These tests are not diagnostic and should not replace medical advice. Sleep issues during menopause are often multifactorial (hot flashes, stress, lifestyle). Consulting a healthcare provider for a comprehensive evaluation is recommended. Evidence grade: marketing/unclear.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-c79ef7d94813df506af40bbf","id":"public-565d561f84dee4a2b59ea2e7","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Is Menopause Check useful for Schlaf?","research_origin_label":"","score":21.93056744,"snippet":"Based on the provided context, there is no direct evidence addressing whether a Menopause Check is useful for sleep. Generally, menopause can affect sleep due to hormonal changes (e.g., declining estrogen and progesterone). A Menopause Check (e.g., blood test measuring FSH, estradiol, progesterone) may provide insight into hormonal status, but evidence linking such tests to improved sleep outcomes is weak. These tests are not diagnostic and should not replace medical advice. Sleep issues during menopause are often multifactorial (hot flashes, stress, lifestyle). Consulting a healthcare provider for a comprehensive evaluation is recommended. Evidence grade: marketing/unclear.","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Is Menopause Check useful for Schlaf?","url":"https://tikki.wiki/wissen/gesundheit/frage/public-565d561f84dee4a2b59ea2e7/is-menopause-check-useful-for-schlaf/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The evidence for a Menopause Check in the context of sleep is weak. Most commercial tests (e.g., salivary hormone panels or DNA-based menopause profiles) rely on markers like estradiol, progesterone, or FSH, but their fluctuations during perimenopause correlate poorly with specific sleep disturbances. Sleep issues in menopause are multifactorial: hot flashes, mood changes, lifestyle, and sleep hygiene are more influential than single hormone levels. The provided context contains no validated studies linking menopause checks to sleep. Some DNA tests claim to capture individual hormone regulation, but the effects of tested SNPs are small and not sleep-specific. Therefore, the predictive value of such checks for sleep quality is low. Medical evaluation (e.g., sleep study, clinically relevant hormone assessment) is recommended. Evidence: marketing/unclear.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-0a7d4aca6b46032a58e30239","id":"public-0661712f2977e6c2eea1d482","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Menopause Check in the context of Schlaf","research_origin_label":"","score":21.88759944,"snippet":"The evidence for a Menopause Check in the context of sleep is weak. Most commercial tests (e.g., salivary hormone panels or DNA-based menopause profiles) rely on markers like estradiol, progesterone, or FSH, but their fluctuations during perimenopause correlate poorly with specific sleep disturbances. Sleep issues in menopause are multifactorial: hot flashes, mood changes, lifestyle, and sleep hygiene are more influential than single hormone levels. The provided context contains no validated studies linking menopause checks to sleep. Some DNA tests claim to capture individual hormone regulation, but the effects of tested SNPs are small and not sleep-specific. Therefore, the predictive value ","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Menopause Check in the context of Schlaf","url":"https://tikki.wiki/wissen/gesundheit/frage/public-0661712f2977e6c2eea1d482/evidence-check-menopause-check-in-the-context-of-schlaf/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The provided context does not contain specific data on the relationship between progesterone and fatigue. In general, progesterone is known to have a sleep-promoting effect, especially during the luteal phase of the menstrual cycle or pregnancy. Evidence comes from observational studies and physiological models, not from large randomized trials. Progesterone acts as a GABA agonist and can cause sedation. However, individual responses vary, and fatigue has many potential causes (e.g., sleep deprivation, stress, thyroid function). Without direct context, the evidence level is unclear. A blood test like the Men’s Wellness Check measures testosterone, cortisol, TSH, etc., but does not explicitly include progesterone. Therefore, a reliable evidence-based answer cannot be derived from the given knowledge.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-116915660f73aacbf43d28b9","id":"public-3b4166a8ff73c87da4471468","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"How are Progesteron and fatigue related?","research_origin_label":"","score":21.81527829,"snippet":"The provided context does not contain specific data on the relationship between progesterone and fatigue. In general, progesterone is known to have a sleep-promoting effect, especially during the luteal phase of the menstrual cycle or pregnancy. Evidence comes from observational studies and physiological models, not from large randomized trials. Progesterone acts as a GABA agonist and can cause sedation. However, individual responses vary, and fatigue has many potential causes (e.g., sleep deprivation, stress, thyroid function). Without direct context, the evidence level is unclear. A blood test like the Men’s Wellness Check measures testosterone, cortisol, TSH, etc., but does not explicitly","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"How are Progesteron and fatigue related?","url":"https://tikki.wiki/wissen/gesundheit/frage/public-3b4166a8ff73c87da4471468/how-are-progesteron-and-fatigue-related/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query asks for an evidence check on 'Hormoncheck Frauen' (women's hormone check) in the context of sleep. The provided context does not directly address this product. Generally, hormones like cortisol, melatonin, estrogen, and progesterone influence sleep. A hormone check might measure cortisol (via blood or saliva) to assess HPA axis activity, which is relevant for sleep regulation. However, single measurements can be misleading due to diurnal variation. Evidence is 'practice' – these are standard clinical tests, but not specifically validated for sleep diagnosis. The context includes cortisol test references (https://mybody-x.com/blogs/bluttest/cortisol-messen-2; https://mybody-x.com/blogs/bluttest/cortisolspiegel-messen) but no comprehensive women's panel. Therefore, evidence is practice-level with caveats: consumer tests may oversimplify; professional interpretation is needed. No strong RCT or GWAS evidence for sleep outcomes from such panels.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-5c2938450395ad42ac66e65a","id":"public-dc12997a7100229480fdfbb7","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Hormoncheck Frauen in the context of sleep","research_origin_label":"","score":21.81512535,"snippet":"The query asks for an evidence check on 'Hormoncheck Frauen' (women's hormone check) in the context of sleep. The provided context does not directly address this product. Generally, hormones like cortisol, melatonin, estrogen, and progesterone influence sleep. A hormone check might measure cortisol (via blood or saliva) to assess HPA axis activity, which is relevant for sleep regulation. However, single measurements can be misleading due to diurnal variation. Evidence is 'practice' – these are standard clinical tests, but not specifically validated for sleep diagnosis. The context includes cortisol test references (https://mybody-x.com/blogs/bluttest/cortisol-messen-2; https://mybody-x.com/b","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Hormoncheck Frauen in the context of sleep","url":"https://tikki.wiki/wissen/gesundheit/frage/public-dc12997a7100229480fdfbb7/evidence-check-hormoncheck-frauen-in-the-context-of-sleep/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}