{"count":10,"index":{"built_at":"2026-07-27T10:10:52.703403+00:00","public_records":55311,"revision":"a9903aa38d047069f5e14e9a"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Menopause Check in the context of Wechseljahre"},"results":[{"answer":"A Menopause Check (Wechseljahre test) typically includes hormone measurements (FSH, estradiol) and sometimes DNA variants linked to age at menopause (e.g., in MCM8, BRSK1). However, the evidence for these genetic markers is weak: GWAS studies show small effect sizes with limited predictive power for individuals. The test cannot diagnose whether menopause is imminent or predict symptom severity. Hormonal fluctuations are normal, and menopause timing is strongly influenced by age, genetics, and lifestyle. A finding suggesting earlier menopause should not cause undue worry but rather prompt medical follow-up. The evidence for consumer menopause tests is mixed: there is some scientific basis, but practical utility is limited. Safety note: Do not make medical decisions based solely on this test; consult a gynecologist for symptoms or fertility concerns.","area":"gesundheit","canonical_id":"gesundheit:canonical-afc5f77ec4b38ebc9ab39bd7","id":"public-d87917e64d8c900a449f7e53","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Menopause Check in the context of Wechseljahre","score":20.69481106,"snippet":"A Menopause Check (Wechseljahre test) typically includes hormone measurements (FSH, estradiol) and sometimes DNA variants linked to age at menopause (e.g., in MCM8, BRSK1). However, the evidence for these genetic markers is weak: GWAS studies show small effect sizes with limited predictive power for individuals. The test cannot diagnose whether menopause is imminent or predict symptom severity. Hormonal fluctuations are normal, and menopause timing is strongly influenced by age, genetics, and lifestyle. A finding suggesting earlier menopause should not cause undue worry but rather prompt medical follow-up. The evidence for consumer menopause tests is mixed: there is some scientific basis, bu","sources":[],"title":"Evidence check: Menopause Check in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-d87917e64d8c900a449f7e53/evidence-check-menopause-check-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query combines HLA-DQ2 (a gene strongly linked to celiac disease) with menopause (Wechseljahre). The provided context contains no evidence or studies connecting HLA-DQ2 to menopause. HLA-DQ2 is a risk marker for autoimmune conditions like celiac disease, not for hormonal changes during menopause. If a test provider suggests such a link, it would be marketing without scientific backing. The evidence level is 'unclear'. Consumers should be cautious and rely on clinical evaluation rather than genetic tests for menopause management.","area":"gesundheit","canonical_id":"gesundheit:canonical-603abc91490e22a136d1ab45","id":"public-cfc93423c41cde552e15ca9a","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: HLA-DQ2 in the context of Wechseljahre","score":20.57698848,"snippet":"The query combines HLA-DQ2 (a gene strongly linked to celiac disease) with menopause (Wechseljahre). The provided context contains no evidence or studies connecting HLA-DQ2 to menopause. HLA-DQ2 is a risk marker for autoimmune conditions like celiac disease, not for hormonal changes during menopause. If a test provider suggests such a link, it would be marketing without scientific backing. The evidence level is 'unclear'. Consumers should be cautious and rely on clinical evaluation rather than genetic tests for menopause management.","sources":[],"title":"Evidence check: HLA-DQ2 in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-cfc93423c41cde552e15ca9a/evidence-check-hla-dq2-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The question about a Fertility Check during menopause (Wechseljahre) is medically complex. Menopause marks a natural decline in fertility, and a simple blood or DNA test cannot reliably predict current or future pregnancy chances. Markers like AMH or FSH can indicate ovarian reserve but are not guarantees. The provided context does not include specific evidence on a Fertility Check in menopause. Therefore, the evidence level is unclear. Consumers should understand that such tests are not diagnostic and that professional medical advice is essential for family planning during this stage.","area":"gesundheit","canonical_id":"gesundheit:canonical-3cb4e0520f3197ab5940f5a3","id":"public-d9bdba88c24f4ec2b1e308a6","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Fertility Check in the context of Wechseljahre","score":20.52323599,"snippet":"The question about a Fertility Check during menopause (Wechseljahre) is medically complex. Menopause marks a natural decline in fertility, and a simple blood or DNA test cannot reliably predict current or future pregnancy chances. Markers like AMH or FSH can indicate ovarian reserve but are not guarantees. The provided context does not include specific evidence on a Fertility Check in menopause. Therefore, the evidence level is unclear. Consumers should understand that such tests are not diagnostic and that professional medical advice is essential for family planning during this stage.","sources":[],"title":"Evidence check: Fertility Check in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-d9bdba88c24f4ec2b1e308a6/evidence-check-fertility-check-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The CLOCK gene is a core component of the circadian rhythm machinery. In the context of menopause (Wechseljahre), hormonal changes, particularly declining estrogen, can disrupt circadian rhythms, leading to sleep disturbances, hot flashes, and metabolic changes. Some studies have investigated CLOCK polymorphisms (e.g., rs1801260) in relation to sleep quality, chronotype, and metabolic syndrome, but direct evidence linking CLOCK variants to menopause-specific symptoms is limited. Most evidence comes from GWAS on chronotype and sleep disorders, not menopause per se. Consumer DNA tests may report CLOCK variants, but the clinical utility for menopause management is unclear. Lifestyle interventions (light exposure, sleep hygiene) are more impactful. Evidence grade: gwas (human-moderate for circadian traits, but weak for menopause). Caveat: no validated genetic test for menopause symptoms.","area":"gesundheit","canonical_id":"gesundheit:canonical-9c1a77f4540b44dc03b99a5c","id":"public-57bbeb8541ef284339d52211","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: CLOCK in the context of Wechseljahre","score":20.48912683,"snippet":"The CLOCK gene is a core component of the circadian rhythm machinery. In the context of menopause (Wechseljahre), hormonal changes, particularly declining estrogen, can disrupt circadian rhythms, leading to sleep disturbances, hot flashes, and metabolic changes. Some studies have investigated CLOCK polymorphisms (e.g., rs1801260) in relation to sleep quality, chronotype, and metabolic syndrome, but direct evidence linking CLOCK variants to menopause-specific symptoms is limited. Most evidence comes from GWAS on chronotype and sleep disorders, not menopause per se. Consumer DNA tests may report CLOCK variants, but the clinical utility for menopause management is unclear. Lifestyle interventio","sources":[],"title":"Evidence check: CLOCK in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-57bbeb8541ef284339d52211/evidence-check-clock-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The role of the FUT2 gene in menopause is not scientifically established. FUT2 determines secretor status and influences vitamin B12 absorption and susceptibility to certain infections (e.g., norovirus). Some studies explore links between B12 deficiency and menopausal symptoms, but there is no robust, reproducible evidence for a direct association of FUT2 variants with menopause onset or progression. Consumer DNA tests often include FUT2 in the context of nutrient metabolism or immune function, not specifically for menopause. The evidence is therefore unclear/speculative. Relying solely on FUT2 genotyping for menopause assessment is not supported. Clinical parameters such as age, hormone levels, and symptoms remain essential.","area":"gesundheit","canonical_id":"gesundheit:canonical-4621b662f6fd9bc1e2073e7c","id":"public-7b566efebff9d1866892d4de","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: FUT2 in the context of Wechseljahre","score":20.37668268,"snippet":"The role of the FUT2 gene in menopause is not scientifically established. FUT2 determines secretor status and influences vitamin B12 absorption and susceptibility to certain infections (e.g., norovirus). Some studies explore links between B12 deficiency and menopausal symptoms, but there is no robust, reproducible evidence for a direct association of FUT2 variants with menopause onset or progression. Consumer DNA tests often include FUT2 in the context of nutrient metabolism or immune function, not specifically for menopause. The evidence is therefore unclear/speculative. Relying solely on FUT2 genotyping for menopause assessment is not supported. Clinical parameters such as age, hormone lev","sources":[],"title":"Evidence check: FUT2 in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-7b566efebff9d1866892d4de/evidence-check-fut2-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The provided knowledge base does not directly address celiac testing in the context of menopause. Celiac disease can cause symptoms like fatigue, bloating, and joint pain, which overlap with common menopause complaints. While medical celiac tests (e.g., tTG-IgA) are well-established, MyBody-X does not explicitly offer such a test in the given context. Evidence for a specific benefit of celiac screening during menopause is unclear – no studies in the context support this. Additionally, menopause itself can alter gut microbiota and hormone levels, complicating interpretation. Conservative advice: If celiac is suspected, a physician should perform standard diagnostic testing. Consumer tests without medical guidance risk misinterpretation. Therefore, the evidence rating is 'unclear'.","area":"gesundheit","canonical_id":"gesundheit:canonical-ee294f73589a7b8563aee5b9","id":"public-3786d4eda790d5164cd9ecd6","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Zöliakie Test in the context of Wechseljahre","score":20.37008937,"snippet":"The provided knowledge base does not directly address celiac testing in the context of menopause. Celiac disease can cause symptoms like fatigue, bloating, and joint pain, which overlap with common menopause complaints. While medical celiac tests (e.g., tTG-IgA) are well-established, MyBody-X does not explicitly offer such a test in the given context. Evidence for a specific benefit of celiac screening during menopause is unclear – no studies in the context support this. Additionally, menopause itself can alter gut microbiota and hormone levels, complicating interpretation. Conservative advice: If celiac is suspected, a physician should perform standard diagnostic testing. Consumer tests wit","sources":[],"title":"Evidence check: Zöliakie Test in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-3786d4eda790d5164cd9ecd6/evidence-check-zoeliakie-test-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Based on the provided context, there is no direct evidence addressing the usefulness of a Menopause Check for 'Wechseljahre'. The context covers MTHFR variants, microbiome tests, IgG food intolerance tests, and allergy tests, but not menopause-specific testing. Therefore, the evidence is unclear. Menopause is a natural physiological transition, and while some direct-to-consumer tests measure hormones (e.g., FSH, estradiol) or offer genetic risk scores, their clinical utility is limited. Hormone levels fluctuate significantly during perimenopause, and diagnosis is typically based on age, menstrual history, and symptoms. Without medical interpretation, test results may cause unnecessary anxiety or lead to inappropriate interventions. Furthermore, many tests lack validated reference ranges for menopausal stages. A conservative approach is to consult a healthcare provider before using such tests. Evidence: unclear. Sources: none in context.","area":"gesundheit","canonical_id":"gesundheit:canonical-6b8b91f26c01251d59919b75","id":"public-5fd41d376b92519a7162cf92","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Is Menopause Check useful for Wechseljahre?","score":20.3566292,"snippet":"Based on the provided context, there is no direct evidence addressing the usefulness of a Menopause Check for 'Wechseljahre'. The context covers MTHFR variants, microbiome tests, IgG food intolerance tests, and allergy tests, but not menopause-specific testing. Therefore, the evidence is unclear. Menopause is a natural physiological transition, and while some direct-to-consumer tests measure hormones (e.g., FSH, estradiol) or offer genetic risk scores, their clinical utility is limited. Hormone levels fluctuate significantly during perimenopause, and diagnosis is typically based on age, menstrual history, and symptoms. Without medical interpretation, test results may cause unnecessary anxiet","sources":[],"title":"Is Menopause Check useful for Wechseljahre?","url":"https://tikki.wiki/wissen/gesundheit/frage/public-5fd41d376b92519a7162cf92/is-menopause-check-useful-for-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The NutriCare | INFINITY DNA-Test is marketed as a comprehensive analysis for metabolism, hormones, and nutrition, including in the context of menopause. However, the scientific evidence for such DNA-based tests in menopause is weak. While certain gene variants (e.g., in vitamin D or estrogen metabolism) may theoretically play a role, robust clinical studies demonstrating a tangible benefit for individual menopause management are lacking. Results are often not reproducible and cannot replace medical hormone or blood analysis. There is also a risk of overinterpretation and unnecessary costs. For menopause, established methods such as hormone profiles, symptom diaries, and medical consultation are far more informative.","area":"gesundheit","canonical_id":"gesundheit:canonical-e748a8a990337d699acf375e","id":"public-1ee158c8078add051cbbd1db","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: NutriCare | INFINITY DNA-Test in the context of Wechseljahre","score":20.34709415,"snippet":"The NutriCare | INFINITY DNA-Test is marketed as a comprehensive analysis for metabolism, hormones, and nutrition, including in the context of menopause. However, the scientific evidence for such DNA-based tests in menopause is weak. While certain gene variants (e.g., in vitamin D or estrogen metabolism) may theoretically play a role, robust clinical studies demonstrating a tangible benefit for individual menopause management are lacking. Results are often not reproducible and cannot replace medical hormone or blood analysis. There is also a risk of overinterpretation and unnecessary costs. For menopause, established methods such as hormone profiles, symptom diaries, and medical consultation","sources":[],"title":"Evidence check: NutriCare | INFINITY DNA-Test in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-1ee158c8078add051cbbd1db/evidence-check-nutricare-infinity-dna-test-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The provided context contains no data on ACTN3 in relation to menopause. ACTN3 is primarily studied for its role in muscle fiber composition and athletic performance (e.g., sprint/power), not for hormonal or menopausal effects. Some mechanistic hypotheses suggest a possible indirect link via muscle metabolism and age-related sarcopenia during menopause, but human evidence is lacking. Without clinical studies or direct associations, any claim connecting ACTN3 to menopause is speculative. DNA testing for this variant offers no actionable guidance for menopausal health. Evidence: mechanistic/unclear. Caveat: no direct evidence in the given context.","area":"gesundheit","canonical_id":"gesundheit:canonical-46a4d65a0a0e3cb7b5f739c2","id":"public-0f6ddd0d65561d8657794b7a","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: ACTN3 in the context of Wechseljahre","score":20.34661034,"snippet":"The provided context contains no data on ACTN3 in relation to menopause. ACTN3 is primarily studied for its role in muscle fiber composition and athletic performance (e.g., sprint/power), not for hormonal or menopausal effects. Some mechanistic hypotheses suggest a possible indirect link via muscle metabolism and age-related sarcopenia during menopause, but human evidence is lacking. Without clinical studies or direct associations, any claim connecting ACTN3 to menopause is speculative. DNA testing for this variant offers no actionable guidance for menopausal health. Evidence: mechanistic/unclear. Caveat: no direct evidence in the given context.","sources":[],"title":"Evidence check: ACTN3 in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-0f6ddd0d65561d8657794b7a/evidence-check-actn3-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query asks about an STI test in the context of menopause. The provided knowledge contexts contain no information about STI tests or their relevance during menopause. From a general medical perspective: STI tests (e.g., for chlamydia, gonorrhea, HIV) are clinically validated procedures whose accuracy is not affected by menopause. However, hormonal changes during menopause may alter infection risk (e.g., due to drier mucous membranes) or symptom perception. An STI test remains a useful screening tool when risk is present. The evidence for test accuracy is human-strong (clinical studies), but the given context lacks any direct link to MyBody-X or specific products. Therefore, the evidence is rated as 'unclear' due to insufficient context.","area":"gesundheit","canonical_id":"gesundheit:canonical-140c683f17a7e09ac632823b","id":"public-38894f6bc952e6db770538ef","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: STI Test in the context of Wechseljahre","score":20.3434912,"snippet":"The query asks about an STI test in the context of menopause. The provided knowledge contexts contain no information about STI tests or their relevance during menopause. From a general medical perspective: STI tests (e.g., for chlamydia, gonorrhea, HIV) are clinically validated procedures whose accuracy is not affected by menopause. However, hormonal changes during menopause may alter infection risk (e.g., due to drier mucous membranes) or symptom perception. An STI test remains a useful screening tool when risk is present. The evidence for test accuracy is human-strong (clinical studies), but the given context lacks any direct link to MyBody-X or specific products. Therefore, the evidence i","sources":[],"title":"Evidence check: STI Test in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-38894f6bc952e6db770538ef/evidence-check-sti-test-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}