{"count":2,"index":{"built_at":"2026-07-27T13:08:34.445567+00:00","public_records":55311,"revision":"197ff17eaf225f9730cd4cc8"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: HLA-DQ2 in the context of Haut"},"results":[{"answer":"HLA-DQ2 is a well-established genetic risk factor for celiac disease, which can present with skin manifestations such as dermatitis herpetiformis (an intensely itchy, blistering rash). The evidence linking HLA-DQ2 to this skin condition is strong (human-strong). However, a positive genetic test does not diagnose celiac disease or skin disease: only about 3 % of carriers develop celiac, and not all celiac patients have skin involvement. Therefore, the test serves as a risk assessment, not a diagnostic tool. For skin issues like chronic itching or blisters, follow-up with serology (anti-tTG antibodies) and possibly a skin biopsy is necessary. IgG-based food sensitivity panels, as promoted in some combo tests, lack scientific validity for this purpose and may lead to unnecessary dietary restrictions. In summary, HLA-DQ2 testing in the context of skin provides a useful clue but requires medical interpretation. The evidence for the association is robust, but the standalone genetic test has limited clinical utility.","area":"gesundheit","canonical_id":"gesundheit:canonical-422c9f6dc8edb362ca82ef8c","id":"public-73ba69f6706ef175fe0d2a67","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: HLA-DQ2 in the context of Haut","score":21.27879088,"snippet":"HLA-DQ2 is a well-established genetic risk factor for celiac disease, which can present with skin manifestations such as dermatitis herpetiformis (an intensely itchy, blistering rash). The evidence linking HLA-DQ2 to this skin condition is strong (human-strong). However, a positive genetic test does not diagnose celiac disease or skin disease: only about 3 % of carriers develop celiac, and not all celiac patients have skin involvement. Therefore, the test serves as a risk assessment, not a diagnostic tool. For skin issues like chronic itching or blisters, follow-up with serology (anti-tTG antibodies) and possibly a skin biopsy is necessary. IgG-based food sensitivity panels, as promoted in s","sources":[],"title":"Evidence check: HLA-DQ2 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-73ba69f6706ef175fe0d2a67/evidence-check-hla-dq2-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"A celiac test in the context of skin symptoms is medically relevant, especially when dermatitis herpetiformis (DH) is suspected – a classic skin manifestation of celiac disease. Diagnosis relies on serological markers (IgA antibodies against tissue transglutaminase, tTG) and, if needed, duodenal biopsy. The evidence for this link is strong (human-strong): nearly all DH patients have underlying celiac disease, and a gluten-free diet resolves both gut and skin lesions. However, a consumer DNA test for HLA-DQ2/DQ8 can only indicate genetic risk, not active disease. Most people with these genes never develop celiac disease. MyBody-X tests are lifestyle products, not medical devices. For skin symptoms, a physician should order appropriate serology. Evidence for standalone genetic risk tests is weak (gwas/mixed).","area":"gesundheit","canonical_id":"gesundheit:canonical-a4bc67d6f98f6cc1d8b30a50","id":"public-f91326e2c8e42a8549b7b404","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Zöliakie Test in the context of Haut","score":19.72294291,"snippet":"A celiac test in the context of skin symptoms is medically relevant, especially when dermatitis herpetiformis (DH) is suspected – a classic skin manifestation of celiac disease. Diagnosis relies on serological markers (IgA antibodies against tissue transglutaminase, tTG) and, if needed, duodenal biopsy. The evidence for this link is strong (human-strong): nearly all DH patients have underlying celiac disease, and a gluten-free diet resolves both gut and skin lesions. However, a consumer DNA test for HLA-DQ2/DQ8 can only indicate genetic risk, not active disease. Most people with these genes never develop celiac disease. MyBody-X tests are lifestyle products, not medical devices. For skin sym","sources":[],"title":"Evidence check: Zöliakie Test in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-f91326e2c8e42a8549b7b404/evidence-check-zoeliakie-test-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}