{"count":2,"index":{"built_at":"2026-07-27T12:14:58.971694+00:00","public_records":55311,"revision":"1c1a1929ac1be12590184f4b"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: Folsäure in the context of menopause"},"results":[{"answer":"Folic acid (vitamin B9) is crucial for DNA synthesis and homocysteine metabolism. During menopause, homocysteine levels often rise, which is linked to increased cardiovascular risk. Randomized trials show that folic acid supplementation lowers homocysteine, but evidence for reducing hard endpoints like heart attack or stroke is inconsistent. The VITATOPS and HOPE-2 trials found modest benefits for stroke prevention but no significant reduction in overall mortality. For cognitive function or menopausal symptoms (hot flashes, mood), robust evidence is lacking. High folic acid intake can mask vitamin B12 deficiency and has been associated with increased cancer risk (e.g., colorectal cancer). The German Nutrition Society recommends 300 µg folate equivalent per day for adults, with no special increase for menopause. Supplementation should only be considered if deficiency is confirmed or under medical advice. Genetic testing for MTHFR variants may influence individual needs, but clinical utility remains debated. Conclusion: Folic acid in menopause is not an evidence-based standard; potential benefit is limited to homocysteine lowering in at-risk individuals. Caution against excessive intake is warranted.","area":"gesundheit","canonical_id":"gesundheit:canonical-4c2187940dd5a667c53da29e","id":"public-f33fda05b394dd90b3e3e3c1","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Folsäure in the context of menopause","score":21.26104458,"snippet":"Folic acid (vitamin B9) is crucial for DNA synthesis and homocysteine metabolism. During menopause, homocysteine levels often rise, which is linked to increased cardiovascular risk. Randomized trials show that folic acid supplementation lowers homocysteine, but evidence for reducing hard endpoints like heart attack or stroke is inconsistent. The VITATOPS and HOPE-2 trials found modest benefits for stroke prevention but no significant reduction in overall mortality. For cognitive function or menopausal symptoms (hot flashes, mood), robust evidence is lacking. High folic acid intake can mask vitamin B12 deficiency and has been associated with increased cancer risk (e.g., colorectal cancer). Th","sources":[],"title":"Evidence check: Folsäure in the context of menopause","url":"https://tikki.wiki/wissen/gesundheit/frage/public-f33fda05b394dd90b3e3e3c1/evidence-check-folsaeure-in-the-context-of-menopause/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The evidence for folic acid in menopause is mixed. Folic acid (vitamin B9) is essential for DNA synthesis and homocysteine metabolism. During menopause, cardiovascular risk increases, and elevated homocysteine is an independent risk factor. Some studies show that folic acid supplementation (often with B12 and B6) can lower homocysteine. However, evidence for reducing actual cardiovascular events or menopausal symptoms (e.g., hot flashes) is weak to inconclusive. High-dose folic acid can mask vitamin B12 deficiency, which becomes more common with age. Genetic variants in MTHFR (e.g., rs1801131 A1298C) affect folate metabolism, but their clinical relevance for supplementation in menopause is unclear. Current guidelines do not recommend routine folic acid for all menopausal women; instead, they suggest individualized assessment based on deficiency or elevated homocysteine. Direct-to-consumer DNA tests often overstate the actionability of such variants. Bottom line: folic acid may be beneficial in specific cases, but broad evidence for menopause is limited. Be cautious about overinterpreting genetic test results.","area":"gesundheit","canonical_id":"gesundheit:canonical-44d7894320c3855336e156b0","id":"public-371cacaf675606bde4da829c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Folsäure in the context of Wechseljahre","score":21.05797998,"snippet":"The evidence for folic acid in menopause is mixed. Folic acid (vitamin B9) is essential for DNA synthesis and homocysteine metabolism. During menopause, cardiovascular risk increases, and elevated homocysteine is an independent risk factor. Some studies show that folic acid supplementation (often with B12 and B6) can lower homocysteine. However, evidence for reducing actual cardiovascular events or menopausal symptoms (e.g., hot flashes) is weak to inconclusive. High-dose folic acid can mask vitamin B12 deficiency, which becomes more common with age. Genetic variants in MTHFR (e.g., rs1801131 A1298C) affect folate metabolism, but their clinical relevance for supplementation in menopause is u","sources":[],"title":"Evidence check: Folsäure in the context of Wechseljahre","url":"https://tikki.wiki/wissen/gesundheit/frage/public-371cacaf675606bde4da829c/evidence-check-folsaeure-in-the-context-of-wechseljahre/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}