{"count":2,"index":{"built_at":"2026-07-27T21:07:39.313434+00:00","public_records":55311,"revision":"aea9bdf6cb0e11a47b427849"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: FUT2 in the context of Haut"},"results":[{"answer":"Evidence for FUT2 in the context of skin health is weak and primarily mechanistic. FUT2 determines secretor status and influences skin microbiome composition, as certain bacteria bind to H antigens on the skin surface. Some studies suggest a link between non-secretor status (inactive FUT2) and increased risk of eczema or dry skin, but results are inconsistent. MyBodyMax DNA tests analyze common SNPs like rs601338, but clinical relevance for personalized skincare is not established. No randomized controlled trials support tailored skincare based on FUT2. Evidence is therefore mechanistic. Caveat: A FUT2 result alone should not prompt changes in skincare or diet without additional biomarkers or medical advice.","area":"gesundheit","canonical_id":"gesundheit:canonical-040b8eb9d8d567b60b0bd948","id":"public-659397352ad08ef08da0a46a","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: FUT2 in the context of Haut","score":22.02212931,"snippet":"Evidence for FUT2 in the context of skin health is weak and primarily mechanistic. FUT2 determines secretor status and influences skin microbiome composition, as certain bacteria bind to H antigens on the skin surface. Some studies suggest a link between non-secretor status (inactive FUT2) and increased risk of eczema or dry skin, but results are inconsistent. MyBodyMax DNA tests analyze common SNPs like rs601338, but clinical relevance for personalized skincare is not established. No randomized controlled trials support tailored skincare based on FUT2. Evidence is therefore mechanistic. Caveat: A FUT2 result alone should not prompt changes in skincare or diet without additional biomarkers o","sources":[],"title":"Evidence check: FUT2 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-659397352ad08ef08da0a46a/evidence-check-fut2-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The evidence for vitamin B12 in the context of skin health is limited and largely mechanistic. Severe B12 deficiency can cause dermatological signs such as hyperpigmentation, vitiligo, or angular stomatitis, but these are rare in well-nourished populations. In individuals without deficiency, B12 supplementation has not been shown to improve skin appearance or conditions. Some consumer DNA tests claim links between B12-related genetic variants (e.g., MTHFR, FUT2) and skin issues, but the effect sizes are small and the evidence is inconsistent. Therefore, the evidence level is 'mechanistic': plausible biological pathways exist, but robust clinical trials are lacking. Before supplementing, a blood test (holotranscobalamin or MMA) is recommended, as high-dose B12 may be unnecessary or even harmful in certain conditions (e.g., kidney disease). Consumer genetic tests can provide hints but not definitive answers.","area":"gesundheit","canonical_id":"gesundheit:canonical-4003443709e2dc89274fd768","id":"public-bdaccf193fface6cc97df609","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: B12 in the context of Haut","score":20.07130571,"snippet":"The evidence for vitamin B12 in the context of skin health is limited and largely mechanistic. Severe B12 deficiency can cause dermatological signs such as hyperpigmentation, vitiligo, or angular stomatitis, but these are rare in well-nourished populations. In individuals without deficiency, B12 supplementation has not been shown to improve skin appearance or conditions. Some consumer DNA tests claim links between B12-related genetic variants (e.g., MTHFR, FUT2) and skin issues, but the effect sizes are small and the evidence is inconsistent. Therefore, the evidence level is 'mechanistic': plausible biological pathways exist, but robust clinical trials are lacking. Before supplementing, a bl","sources":[],"title":"Evidence check: B12 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-bdaccf193fface6cc97df609/evidence-check-b12-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}