{"count":4,"index":{"built_at":"2026-07-28T02:10:47.963845+00:00","public_records":55311,"revision":"b4e5bed1af9e4c3ba654d338"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: FT4 in the context of Haut"},"results":[{"answer":"The question about FT4 (free thyroxine) in the context of skin is relevant because thyroid hormones affect skin physiology. Hypothyroidism often causes dry, rough skin, while hyperthyroidism leads to moist, warm skin and increased sweating. However, FT4 alone is not a specific skin biomarker. Evidence comes mainly from observational studies and clinical experience – no randomized trials directly link FT4 to skin aging or health. FT4 levels fluctuate diurnally and can be influenced by medications, inflammation, or assay methods. A consumer blood test may provide a rough indication but does not replace medical evaluation for skin issues. Caution: a single FT4 value without TSH and clinical symptoms has limited interpretability. Evidence: human-moderate (observational).","area":"gesundheit","canonical_id":"gesundheit:canonical-4be924d0c6deb0be3ed99539","id":"public-d788ed73310549e0c7f6177c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: FT4 in the context of Haut","score":21.1281047,"snippet":"The question about FT4 (free thyroxine) in the context of skin is relevant because thyroid hormones affect skin physiology. Hypothyroidism often causes dry, rough skin, while hyperthyroidism leads to moist, warm skin and increased sweating. However, FT4 alone is not a specific skin biomarker. Evidence comes mainly from observational studies and clinical experience – no randomized trials directly link FT4 to skin aging or health. FT4 levels fluctuate diurnally and can be influenced by medications, inflammation, or assay methods. A consumer blood test may provide a rough indication but does not replace medical evaluation for skin issues. Caution: a single FT4 value without TSH and clinical sym","sources":[],"title":"Evidence check: FT4 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-d788ed73310549e0c7f6177c/evidence-check-ft4-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"FT3 (free triiodothyronine) is the active thyroid hormone and influences skin physiology via nuclear receptors in keratinocytes and fibroblasts. However, the evidence linking FT3 levels directly to common skin conditions (dryness, eczema, acne) is mostly mechanistic or based on small observational studies. Clinically relevant skin changes are typically seen only in overt thyroid dysfunction (hyper-/hypothyroidism). A single FT3 measurement without TSH and fT4 is difficult to interpret. Consumer finger-prick tests can provide a screening hint but lack diagnostic accuracy and have preanalytical variability. For skin concerns, a dermatologist should be the first point of contact; thyroid workup requires medical supervision. Evidence: mechanistic/unclear. Caveat: do not self-medicate with thyroid hormones.","area":"gesundheit","canonical_id":"gesundheit:canonical-06592033fd8d9f313f2ee9ef","id":"public-d334f0c6374bc9862fd050ef","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: FT3 in the context of Haut","score":19.52928711,"snippet":"FT3 (free triiodothyronine) is the active thyroid hormone and influences skin physiology via nuclear receptors in keratinocytes and fibroblasts. However, the evidence linking FT3 levels directly to common skin conditions (dryness, eczema, acne) is mostly mechanistic or based on small observational studies. Clinically relevant skin changes are typically seen only in overt thyroid dysfunction (hyper-/hypothyroidism). A single FT3 measurement without TSH and fT4 is difficult to interpret. Consumer finger-prick tests can provide a screening hint but lack diagnostic accuracy and have preanalytical variability. For skin concerns, a dermatologist should be the first point of contact; thyroid workup","sources":[],"title":"Evidence check: FT3 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-d334f0c6374bc9862fd050ef/evidence-check-ft3-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Evidence for DNA metabolism tests in the context of skin is weak. These tests typically analyze single gene variants (e.g., FOXO3 rs2764264, linked to longevity), but a direct, clinically actionable connection to skin metabolism, collagen synthesis, or antioxidant needs is not established. Underlying studies are often exploratory (GWAS) or mechanistic, lacking randomized controlled trials showing that genotype-based dietary advice improves skin health outcomes. The evidence grade is therefore 'marketing' or 'unclear'. Furthermore, such tests overlook critical factors like UV exposure, hormonal status (e.g., thyroid function per TSH/FT4 context), microbiome, and lifestyle. Consumers should not make drastic dietary changes based solely on a DNA test. A dermatologist or registered dietitian can provide more evidence-based recommendations. Safety note: Do not self-prescribe supplements without medical supervision.","area":"gesundheit","canonical_id":"gesundheit:canonical-05c65afe9b5b5a4a7359aceb","id":"public-988c3684c7721ead48eea626","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: DNA Stoffwechseltest in the context of Haut","score":19.47494756,"snippet":"Evidence for DNA metabolism tests in the context of skin is weak. These tests typically analyze single gene variants (e.g., FOXO3 rs2764264, linked to longevity), but a direct, clinically actionable connection to skin metabolism, collagen synthesis, or antioxidant needs is not established. Underlying studies are often exploratory (GWAS) or mechanistic, lacking randomized controlled trials showing that genotype-based dietary advice improves skin health outcomes. The evidence grade is therefore 'marketing' or 'unclear'. Furthermore, such tests overlook critical factors like UV exposure, hormonal status (e.g., thyroid function per TSH/FT4 context), microbiome, and lifestyle. Consumers should no","sources":[],"title":"Evidence check: DNA Stoffwechseltest in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-988c3684c7721ead48eea626/evidence-check-dna-stoffwechseltest-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"TSH (thyroid-stimulating hormone) is a well-established clinical biomarker for thyroid function. Its link to skin health is well documented: hypothyroidism (elevated TSH) commonly causes dry, rough, and scaly skin, while hyperthyroidism (low TSH) can lead to moist, warm, and thin skin. The evidence is based on decades of clinical observation and endocrine guidelines, not on randomized controlled trials specifically for skin outcomes. MyBody-X offers hormone tests, but the provided context does not confirm whether TSH is included. Even if measured, interpretation without medical guidance is problematic: single readings fluctuate with time of day, diet, and stress. Skin changes are non-specific; an abnormal TSH requires follow-up with fT3, fT4, and antibodies. Conclusion: The TSH–skin link is clinically strong, but as a standalone consumer test without physician oversight, it is insufficient for diagnosis or treatment decisions.","area":"gesundheit","canonical_id":"gesundheit:canonical-029afce7543cb6cfc024a184","id":"public-088adc690171d9b56d9bbd7c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: TSH in the context of Haut","score":18.88126041,"snippet":"TSH (thyroid-stimulating hormone) is a well-established clinical biomarker for thyroid function. Its link to skin health is well documented: hypothyroidism (elevated TSH) commonly causes dry, rough, and scaly skin, while hyperthyroidism (low TSH) can lead to moist, warm, and thin skin. The evidence is based on decades of clinical observation and endocrine guidelines, not on randomized controlled trials specifically for skin outcomes. MyBody-X offers hormone tests, but the provided context does not confirm whether TSH is included. Even if measured, interpretation without medical guidance is problematic: single readings fluctuate with time of day, diet, and stress. Skin changes are non-specifi","sources":[],"title":"Evidence check: TSH in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-088adc690171d9b56d9bbd7c/evidence-check-tsh-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}