{"count":1,"index":{"built_at":"2026-07-28T07:29:22.951961+00:00","public_records":55311,"revision":"879d1bc35e55e45bbd75b307"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: ADH1B in the context of Haut"},"results":[{"answer":"Evidence for ADH1B in the context of skin is weak to mechanistic. ADH1B encodes alcohol dehydrogenase, which metabolizes ethanol to acetaldehyde. Certain variants (e.g., rs1229984) increase enzyme activity, leading to rapid acetaldehyde accumulation, causing facial flushing ('Asian flush'). Beyond flushing, acetaldehyde may contribute to oxidative stress and inflammation, potentially affecting skin aging or acne – but these links are based on mechanistic studies and observational data, not robust clinical trials. MyBody-X includes ADH1B in nutrigenetic panels, but its predictive value for specific skin outcomes is limited. A positive result does not guarantee skin issues; lifestyle, diet, and other genes are more influential. Safety note: With a high-activity ADH1B variant, alcohol consumption increases acetaldehyde-related risks (headache, nausea, long-term cancer risk). Evidence rating: mechanistic.","area":"gesundheit","canonical_id":"gesundheit:canonical-c83cd3ee8a33ce6c6309a718","id":"public-1de79308db3ae2c500387b66","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: ADH1B in the context of Haut","score":23.39904043,"snippet":"Evidence for ADH1B in the context of skin is weak to mechanistic. ADH1B encodes alcohol dehydrogenase, which metabolizes ethanol to acetaldehyde. Certain variants (e.g., rs1229984) increase enzyme activity, leading to rapid acetaldehyde accumulation, causing facial flushing ('Asian flush'). Beyond flushing, acetaldehyde may contribute to oxidative stress and inflammation, potentially affecting skin aging or acne – but these links are based on mechanistic studies and observational data, not robust clinical trials. MyBody-X includes ADH1B in nutrigenetic panels, but its predictive value for specific skin outcomes is limited. A positive result does not guarantee skin issues; lifestyle, diet, an","sources":[],"title":"Evidence check: ADH1B in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-1de79308db3ae2c500387b66/evidence-check-adh1b-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}